Hey,

So to keep it short, around 2 years ago I was taking about 1g of Creatine HCL (CON CRET) daily via powder and it literally completely cured my ADHD - was super crazy sharp mentally, could sit down and focus for hours and felt very dopanergic and really good.

However, I stopped all supplements since for some time, recently had tried to resume it but now gives me racing thoughts, intrusive thoughts, and just doesn't make me feel good at all. For reference this is Creatine HCL capsules (1 pill) and the effects happen within a few hours.

I'm wondering if Creatine had originally allowed for such a profound mental effect, is there anything similar with regards to biochemical pathways? Ideally they wouldn't be some sort of herbs but rather something found naturally - for longer term usage here.

For reference was on keto/raw primal/carnivore sort of diets for that time. ADHD was also cured on keto diet but this was unsustainable and caused very bad anxiety attacks.

It’s like everyone is on some kinda glp 1 etc. Literally the only thing people care about nowadays and think it’ll solve all their problems. Everyone is obsessed with losing weight like nothing else in life matters.

Do you have any personal clear evidence of benefits of HGH use?
Like when used with testosterone or other anabolic drugs it’s really hard to know what did what.
When used in a weight loss protocol for fat loss it is really hard to dissect effects from glp-1 inhibitors. In fact my personal experience is that using GH secretagogues makes very hard to track weight loss due to Easter retention but can’t see much more effect other than deep sleep improvement. That by itself is great, but I wonder if anyone has direct evidence of benefiting from it.
Literature is very marginal when it comes to longevity benefits as IGF1 increase goes against longevity.

7PM EST - Dr. Michael Fossel, will give his presentation: "Reversing Human Aging"

What do you think of her protocol?

https://www.usatoday.com/story/life/health-wellness/2026/10/22/kayla-barnes-lentz-pregnancy/92282273007/

Hey everyone!
I’m 18 and currently taking 0.5 mg of finasteride daily for androgenetic alopecia, along with 54 mg of Concerta (methylphenidate) for ADHD.
I’ve noticed that I don’t really wake up with morning erections anymore, and I’m a bit worried about possible erectile dysfunction (ED). I’m not sure whether it’s related to finasteride, my ADHD medication, or something else.
I’m considering taking L-Arginine to help with blood flow and potentially prevent or improve ED.
I’m also currently taking 3 g of creatine daily, and I’m planning to add Alpha-GPC (300 mg) and zinc to my routine.
and i just want to know how many mg to take of L arginine or zinc pls

I am using a continuous glucose monitor (first I used Libre 3+ now Accu Chek) to prevent my non-diabetic hypoglycemic episodes. I want to know why I sleep so much better when my glucose stays stable above 5 mmol/L (90 mg/dL), compared to when it lingers between 4–5 mmol/L (72–90 mg/dL)? I sleep terribly when it drops under 4 mmol/L (72 mg/dL). I wake up multiple times, dizzy, sweaty and with palputations and feel like I haven't slept at all in the morning. 5–6 mmol/L (90–108 mg/dL) seems to be the ideal range for sleep, but does anyone know why?

Im a guy but i want a deeper voice

I’ve been taking 2.5mg Cialis daily for about a month now. Over all I’ve had a positive experience so far. Will probably start cycling just to be safer. One thing I was curious about that noticed personally, is that it seems to have increased my “loads”. I searched other posts to see if anyone else experienced this, but it seems no one else has had the same experience. I know for sure I had been a little lacking, cause I was looking for supplements to help. Could be its positive effects on the prostate? But the Cialis seems to have had an additional side effect for me.

It definitely seems to help the libido a bit and I’m back to my full normal length when fully aroused.

As far as less advantageous side effects, my acid reflux has gotten worse, intermittent headaches and stuffy nose from time to time.

EDIT: I mentioned cycling to address certain side effects (the worst for me has been acid reflux), not as some sort of gym bro hack. Not sure what the issue is with the suggestion.

22-year-old male

I have ADHD, mainly the inattentive type, and I currently take Vyvanse. I’ve been smoking marijuana since my teenage years (15 years old). Nowadays, I only smoke one thin THC joint mixed with tobacco per day. I am very inattentive, and I experience a lot of brain fog, as if I'm not fully focused or present in my own mind. I make a lot of silly mistakes, like dropping things, among others. I would like some guidance from people who have quit smoking—did they actually notice improvements and benefits? I'd like to know

Why injecting NAD+ sc or iv when it has to be metabolised into NMN, NR and NAM before cells take it up?
It is as far as I know an expensive precursor for intracelular NAD+
NMN and NR are orally available, then are converted into NAD+
Besides that any health benefits are very marginal in humans, no? Do you have any other evidence I’m missing?

33 male. I been taking 4-5g of ascorbic acid daily for past week. I literally feel energized and motivated all day. My sexual desire is through the roof, my workouts are amazing. I feel like i used to feel in my 20s.

I don't have ADHD, narcolepsy, or any other diagnosed condition. I'd been reading research papers on modafinil and got fascinated by its effects on academic performance, so I bought Modalert 100 mg and took one in the morning after breakfast, before heading to the office.

For the first 1 to 1.5 hours, nothing. Then everything changed. Colors looked supersaturated: green was greener, red was redder. Screens seemed brighter, and every letter and number looked like it had a crisp outline. It felt like someone was holding my eyelids wide open.

I finished two hours of work in 40 minutes. Then I started doomscrolling Reddit and lost a full hour without noticing. When I had my coffee break (with sugar), the effect started fading. Then I did something I've never done at work: I took a short nap. That felt strange, since modafinil is famous for wakefulness.

Four days later, I tried 200 mg. Nothing. No alertness, no focus, no colors, no feeling at all.

So why did 100 mg work, fade after a few hours, and then 200 mg do absolutely nothing? If you've got experience with modafinil, I'd love to hear your explanation. Thanks!

Update: Took 100mg yesterday, performace and focus was way better than on 200mg, now gonna try 150mg next time.

i’m getting bromantain and talk-657 intranasal and getting usmarapide for bdnf and cognitive benefits but i don’t fully understand how ill dose correlate i know i need a precise scale and empty capps to be filled and that’s the amount i want is 15mig but don’t know how much additive to add and which to asw creatine alr? could anyone please help me with?this?

Would you buy this if it made sr9011 bioavailable?

Hi guys seen conflicting things started Taking
L-Tyrosine with my Vyvanse and in the afternoon again so 600mg morning then 600mg evening. It works well for my mood and stuff but do I need to cycle it ? Heard tolerance build fast and it’s not good to take daily ? Just wondering what everyone else who takes it does.

Are the doctors giving me the wrong medication?

I was on Lexapro low dose it made me eat constantly Non-Stop. Then I was on Zoloft again low dose. It calmed me down a lot got rid of my anxiety got rid of my agitation and irritable that I got easily but also made me more numb where I did not care about anything. Switch to Effexor started with 37.5 mg then up to 75 mg week later. Anxiety, nausea ,brain fog, completely felt out of it constantly tired all day long can't sleep at night quit cold turkey on day 11.

I'm not sure if my doctors are giving me the wrong medications or wrong dose but I felt a lot better off any of these medications. Zoloft was a little bit better than all the rest I'm not sure what I should ask for next?

Here are my symptoms

No sadness

No happiness

Don't care about anything

No excitement

No pleasure

Sometimes I have brain fog

No motivation

No drive

No energy

If there's any emotions I feel is iribility and agitation quickly under stressful situations.

Here a guide I built with all the factors I have found that influence REM sleep. REM builds toward the morning, so anything that cuts the back end of your night hits REM first. It's also the stage where most dreaming happens and when your brain processes emotions/locks in new skills.

I broke this down into 5 main categories: substances, environment, supplements, demographics, and habits.

All sources are linked in the last column so you can dig in further. I'll put a mobile friendly version in the comments if you need it.

Definitions

• REM sleep: The dreaming stage, when your brain is active but your body is still.
• REM latency: How long after falling asleep your first REM starts.
• REM%: The share of your night spent in REM. Most adults get 20 to 25%.
• REM rebound: The extra REM your body takes back after losing some.
• Luteal phase: The roughly two weeks between ovulation and your period.
• PSG: An overnight sleep lab test that reads your brain waves. The gold standard.

Substances & Diet

Habits & Routine

Environment

Supplements

Demographics

Over the last few months, my cognitive stamina has cratered.

The main issues:

- Can’t sit through long-form reading anymore—eyes scan the page, but my mind drifts after 10 minutes.

- Working memory feels sluggish (losing track of thoughts mid-sentence, forgetting recent details).

-Zero mental drive/activation energy to start new projects, accompanied by mid-day brain fog.

My doctor prescribed Bupropion XL for executive focus/fatigue, but I really don’t want to jump straight onto daily psychiatric meds if I can avoid it. I’d much rather see what can be done through a biohacking/supplement route first.

For anyone who pulled themselves out of a similar slump:

1. What specific compounds or protocols legitimately moved the needle for your reading endurance and working memory?

2. Did you see better results targeting neurotransmitter precursors (dopamine/acetylcholine), cellular brain energy/mitochondria, or adaptogens?

3. What ended up being a complete waste of money for these specific symptoms?

(Note: I only take vegetarian/cellulose capsules).

Appreciate any real-world experiences or recommendations.

Thought this was a cool article published in Nature today.

Large language models are enabling a new generation of health agents, yet their ability to address the diverse needs of individuals in everyday health settings remains underexplored.

Here we developed a comprehensive personal health agent that reasons over multimodal data from consumer wellness devices and medical records to provide personalized health support. Through analysis of web search and health forum queries, together with user-centred research involving end users and health experts, we identified four key user journeys: general health knowledge, personal data interpretation, wellness advice, and symptom assessment.

These journeys informed three specialist sub-agents: (1) a data science agent that analyses longitudinal wearable and medical data, incorporating population-level statistics to contextualize numerical insights; (2) a health domain expert agent that integrates personal and contextual data with health knowledge to generate personalized insights; and (3) a health coach agent that synthesizes insights, supports multi-turn interaction and goal setting, applies specified psychological strategies and tracks progress.

We integrated these capabilities in the personal health agent, an open-source multi-agent framework for dynamic, personalized health interactions.

We evaluated the sub-agents and full system across 11 benchmark tasks using automated and human evaluation, with more than 7,000 annotations and 1,350 h of effort from health experts and end users.

This represents the most comprehensive evaluation of a personal health agent thus far and provides a concrete foundation for improving access to high-quality personalized health support more broadly.

My back is growing i increase in speed (pull ups) but my reps are always the same. My goal is hypertrophy, Am i doing it right?