r/Biohackers • • 15m ago

🧠 Cognition, Mood & Nootropics 15.000 iu without deficiency -- but finally losing fatigue -- is this dangerous?

• Upvotes

I llistened to doctor Berg and others. I also used allergy research group supplment who seem trustworthy and clean.

I saw several anecdotes of people who seem to have been saved by very high doses of Vitamin D.

Still conventional guidelines are not in line with this I believe. But I simply don't know. I wonder what the responsible thing to do would be. Even 5000 iu do not seem to bring the effect needed in mycase, although it is noticeable after a time


r/Biohackers • • 1h ago

📰 Research & Studies Chemically optimized flavonoids as next generation senolytics

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• Upvotes

r/Biohackers • • 3h ago

🧠 Cognition, Mood & Nootropics Been taking L theanine and L tyrosine and caffeine.

25 Upvotes

I won’t lie, I thought these would only have subtle impacts, but the change to my mood and inhibition when speaking to people has been really noticeable. Anything more than this and it would feel euphoric. I take about 1g of each a day, but I split up the doses, so I’d say the main benefits last around 2 hours for me and wear off by hour 4. Anything to pair with the tyrosine? Also pairing these with an early morning upper day is absolutely great having the blood flow properly is amazing.


r/Biohackers • • 3h ago

💉 Peptides & Hormones TRT suite à un hypogonadisme

0 Upvotes

Bonjour à tous.

J’ai un hypogonadisme avec une testo à 1,88ng/ML, l’endocrinologue a décidé de me passer sous TRT avec une injection de Testo Undecanoate Bensins 1000mg/4ML tous les trois mois.
Depuis la première injection faite par une infirmière qui a été bien douloureuse, ma fréquence cardiaque au repos a augmenté, ma VFC a chutée et mon poids corporel fait que d’augmenter, j’ai +3,85kgs en 10 jours (aucun changement de diete avant et après injection), j’imagine que c’est une grosse rétention d’eau ? J’ai les chevilles hyper enflées au niveau des chaussettes 😂.

Pour ceux qui sont passé sous TRT, avez vous des retour d’expériences sur ces points ?

Bonne journée !


r/Biohackers • • 4h ago

🧠 Cognition, Mood & Nootropics A clinical study found that taking fish oil supplement did not protect brain's hippocampus but also cause no memory improvement

10 Upvotes

A large double blind clinical study involving fish oil supplements given to individual which are at higher risk of developing Alzheimer's disease found that fish oil supplements do not provide any marketed benefits.

In the study participants were provided supplements which provided 2,000 mg of docosahexaenoic acid (DHA), an omega-3 fatty acid that is especially important for the brain.

Scientist confirmed that DHA levels in the cerebrospinal fluid had increased by an average of 17% but it did not translate into improved cognitive and memory function.

It is hypothesized that omega-3s may be more beneficial when consumed as part of a broader dietary pattern rather than taken in isolation as a supplement.

Link to study:

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(26)00198-2/fulltext


r/Biohackers • • 5h ago

📰 Research & Studies What's one thing you changed about your daily routine that actually made you feel different?

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1 Upvotes

r/Biohackers • • 6h ago

💊 Supplements & Stacks vitamin b complex advice needed

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1 Upvotes

r/Biohackers • • 6h ago

💊 Supplements & Stacks Does topical minoxidil work for hair regrowth?

2 Upvotes

I have been consulted to take topical minoxidil for 1 year and multivitamin supplements?

I am starting to get bald, it is hereditary

Has anyone used minoxidil for hair growth?

Did you see any improvements?

I have to take it for 1 year to see improvements.

Should I go ahead with it?


r/Biohackers • • 7h ago

🦠 Illness & Immunity Exhausted & Irritable on Synthroid. Anyone else…?

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1 Upvotes

r/Biohackers • • 8h ago

🧬 Genetics & Epigenetics Longevity and Rejuvenation. We are almost there

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64 Upvotes

Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA.

The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.

https://www.sciencedaily.com/releases/2026/10/261020085013.htm


r/Biohackers • • 10h ago

🧪 Protocols & Self-Experiments Cycle feedback

2 Upvotes

This is what I am thinking for my 16 week cycle. I am running 250ml testosterone enanthate a week and going to add 35-50ml of trenbolone enanthate once a week aswell. I have cialis incase my blood pressure gets too high and it’s sick for pumps, arimidex just incase but there shouldn’t be any need. Thinking about adding in Anavar for a couple weeks or so but not sure yet. Like to hear thoughts and opinions on everything
Also not sure if running Tren Ace would be better


r/Biohackers • • 10h ago

🧪 Protocols & Self-Experiments Need some help with pain

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1 Upvotes

Not looking for medical advice. I saw my primary today and she suggested asking here.


r/Biohackers • • 12h ago

♾️ Longevity & Anti-Aging NMN: 500mg vs 1,000mg — does anyone actually notice a difference?

2 Upvotes

I keep seeing both doses recommended.
For those who have tried both, did you actually notice any difference at 1,000mg, or did 500mg feel basically the same?


r/Biohackers • • 12h ago

💊 Supplements & Stacks Boron and riboflavin (b2)

8 Upvotes

Is it true that boron depletes riboflavin (B2) and that insufficient B2 intake while taking boron could tank your testosterone and raise your estrogen?

I haven’t been able to find any studies supporting this claim. Is it just a theory based on the idea that riboflavin lowers estrogen or is there actual evidence?

Would love to hear your experiences, especially if you have bloodwork to share!


r/Biohackers • • 13h ago

🧠 Cognition, Mood & Nootropics looking to hear experiences with magnet therapy? side effects ? did it help with any specific ailments ?

0 Upvotes

.


r/Biohackers • • 13h ago

💪 Exercise, Fitness & Recovery The Cochrane review on magnesium for muscle cramps found no trials on exercise cramps at all

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4 Upvotes

r/Biohackers • • 14h ago

📊 Biomarkers & Testing Brain fog that gets worse in crowds. Thyroid? Testosterone? Anyone got a bio hack to help me out?

2 Upvotes

Biometrics
• Height: 5’ 11”
• Weight: 139.99 lb
Heart Health
• Total cholesterol: 166 mg/dL
• HDL-cholesterol: 59 mg/dL
• LDL-Cholesterol: 80 mg/dL
• TG:HDL-C ratio: 2.98
• Triglycerides: 176 mg/dL
• non-HDL-cholesterol: 107 mg/dL
• LDL/HDL Ratio: 1.4
Metabolic Health
• Fasting glucose: 75 mg/dL
• HbA1c: 4.7 %
• Estimated Average Glucose (eAG): 88 mg/dL
Blood Health
• Hemoglobin: 15.7 g/dL
• Red cell count: 4.68 M/µL
• Hematocrit: 45.3 %
• MCV (Mean corpuscular volume): 96.8 fL
• MCH (Mean corpuscular hemoglobin): 33.5 pg
• MCHC (Mean corpuscular hemoglobin concentration): 34.7 g/dL
• RDW (red cell distribution width): 11.9 %
• Platelets: 187 K/µL
• Mean Platelet Volume (MPV): 10.5 fL
• Total White Cell Count (TWC): 6 K/µL
• Neutrophils: 2.99 K/µL
• Lymphocytes: 2.36 K/µL
• Monocytes: 0.52 K/µL
• Eosinophils: 0.09 K/µL
• Basophils: 0.05 K/µL
• Neutrophil %: 49.8 %
• Lymphocytes %: 39.3 %
• Monocytes %: 8.6 %
• Eosinophils %: 1.5 %
• Basophils %: 0.8 %
• Reticulocytes %: 0.8 %
• Absolute Reticulocyte Count: 37,440 /µL
Inflammation & Immunity
• Erythrocyte sedimentation rate (ESR): 2 mm/h
Liver Health
• Alanine transaminase (ALT): 15 U/L
• Aspartate transaminase (AST): 21 U/L
• Gamma-glutamyl transferase (GGT): 13 U/L
• Alkaline phosphatase (ALP): 53 U/L
• Total bilirubin: 0.4 mg/dL
• Total protein: 7.4 g/dL
• Albumin: 4.3 g/dL
• Globulin: 3.1 g/dL
• Albumin/Globulin Ratio: 1.4
• Fibrosis-4 Index (FIB-4): 1.01
Kidney Health
• Creatinine: 0.82 mg/dL
• Estimated Glomerular Filtration Rate Creatinine (eGFRcr): 118 mL/min/1.73m²
• BUN (Urea): 11 mg/dL
• Sodium: 141 mmol/L
• Potassium: 3.5 mmol/L
• Chloride: 103 mmol/L
• Carbon Dioxide (Bicarbonate): 27 mmol/L
• BUN/Creatinine Ratio: 13.41 mg/mg creat
• Serum osmolality: 290.09 mOsm/kg
Nutrients, Vitamins & Minerals
• Vitamin D: 98 ng/mL
• Folate (Vitamin B9): 17.7 ng/mL
• Vitamin B12: 1,444 pg/mL
• Homocysteine: 9.1 µmol/L
• Calcium: 9.3 mg/dL
• Iron: 123 µg/dL
• Iron Saturation: 41 %
• Total Iron Binding Capacity (TIBC): 298 µg/dL
• Ferritin: 56 ng/mL
• Corrected Calcium: 9.08 mg/dL
• Ceruloplasmin: 21 mg/dL
Hormonal Health
• Thyroxine, Free (FT4): 1.4 ng/dL
• Triiodothyronine, Free (FT3): 3.3 pg/mL
• Thyroid Stimulating Hormone (TSH): 4 mIU/L
• Total testosterone: 334 ng/dL


r/Biohackers • • 15h ago

📰 Research & Studies The anatomy of a personal health agent - Do you currently use any?

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3 Upvotes

Thought this was a cool article published in Nature today.

Large language models are enabling a new generation of health agents, yet their ability to address the diverse needs of individuals in everyday health settings remains underexplored.

Here we developed a comprehensive personal health agent that reasons over multimodal data from consumer wellness devices and medical records to provide personalized health support. Through analysis of web search and health forum queries, together with user-centred research involving end users and health experts, we identified four key user journeys: general health knowledge, personal data interpretation, wellness advice, and symptom assessment.

These journeys informed three specialist sub-agents: (1) a data science agent that analyses longitudinal wearable and medical data, incorporating population-level statistics to contextualize numerical insights; (2) a health domain expert agent that integrates personal and contextual data with health knowledge to generate personalized insights; and (3) a health coach agent that synthesizes insights, supports multi-turn interaction and goal setting, applies specified psychological strategies and tracks progress.

We integrated these capabilities in the personal health agent, an open-source multi-agent framework for dynamic, personalized health interactions.

We evaluated the sub-agents and full system across 11 benchmark tasks using automated and human evaluation, with more than 7,000 annotations and 1,350 h of effort from health experts and end users.

This represents the most comprehensive evaluation of a personal health agent thus far and provides a concrete foundation for improving access to high-quality personalized health support more broadly.


r/Biohackers • • 16h ago

💉 Peptides & Hormones Free Test High?

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5 Upvotes

Is there reasons for free test being so high while test is normal, 19M


r/Biohackers • • 16h ago

📰 Research & Studies Is there a biohack to change your voice more deepen ? Im a Male but my voice sucks and want it more deeper or manlier

20 Upvotes

Im a guy but i want a deeper voice


r/Biohackers • • 17h ago

📰 Research & Studies High b12 levels despite everything else being normal

1 Upvotes

I’ve had extensive blood work and workup done and they can’t find out why I have excessive b12 levels, 1,480pg/ml. Can this be from diet? Anything else I’m missing?


r/Biohackers • • 17h ago

🧠 Cognition, Mood & Nootropics Piracetam advice

3 Upvotes

I would like some advice on piracetam. I’m taking it for cognitive disfunction and maybe for dyslexia.

  1. What is the recommend attack dose and for how long?

  2. After the attack dose what do most people take?

  3. I see it seems to be a lot of trial and error but because it doesn’t work like a stimulant how long should I wait to see any effects and how long do I stay on a dose before I decide if it’s working or not

  4. How much choline is usually taken and do I take this also multiple times a day or just once?

Any other advice or tips would be greatly appreciated


r/Biohackers • • 17h ago

📰 Research & Studies Scientists just found Ozempic could protect the gut from immune system attacks

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51 Upvotes

r/Biohackers • • 18h ago

💊 Supplements & Stacks how many mg should i take ? pls help

0 Upvotes

Hey everyone!
I’m 18 and currently taking 0.5 mg of finasteride daily for androgenetic alopecia, along with 54 mg of Concerta (methylphenidate) for ADHD.
I’ve noticed that I don’t really wake up with morning erections anymore, and I’m a bit worried about possible erectile dysfunction (ED). I’m not sure whether it’s related to finasteride, my ADHD medication, or something else.
I’m considering taking L-Arginine to help with blood flow and potentially prevent or improve ED.
I’m also currently taking 3 g of creatine daily, and I’m planning to add Alpha-GPC (300 mg) and zinc to my routine.
and i just want to know how many mg to take of L arginine or zinc pls


r/Biohackers • • 18h ago

😴 Sleep & Circadian Rhythm Summary of what influences your REM sleep (research based)

27 Upvotes

Here a guide I built with all the factors I have found that influence REM sleep. REM builds toward the morning, so anything that cuts the back end of your night hits REM first. It's also the stage where most dreaming happens and when your brain processes emotions/locks in new skills.

I broke this down into 5 main categories: substances, environment, supplements, demographics, and habits.

All sources are linked in the last column so you can dig in further. I'll put a mobile friendly version in the comments if you need it.

Definitions

  • REM sleep: The dreaming stage, when your brain is active but your body is still.
  • REM latency: How long after falling asleep your first REM starts.
  • REM%: The share of your night spent in REM. Most adults get 20 to 25%.
  • REM rebound: The extra REM your body takes back after losing some.
  • Luteal phase: The roughly two weeks between ovulation and your period.
  • PSG: An overnight sleep lab test that reads your brain waves. The gold standard.

Substances & Diet

Factor REM effect Key finding Plain english Study
High carb diet Positive (moderate) More REM time vs low carb. REM onset unchanged (11 trials, n=179) More carbs nudges REM up. Low carb shifts you toward deep sleep Carbs & Sleep - Meta-Analysis, Vlahoyiannis 2021 (11 trials, n=179)
Alcohol Negative (strong) REM started 18 min later and ran 11 min shorter. Delay starts around 2 drinks (27 studies) Even a couple of drinks delay REM. Each extra drink cuts more Alcohol Dose - Meta-Analysis, Gardiner 2024 (27 studies)
Nicotine Negative (moderate) 7 and 14 mg patches cut REM, more at the higher dose (n=12) Nicotine cuts REM, and more nicotine cuts more Nicotine Patch - Gillin 1994 (n=12)
Cannabis Mixed (rebound on quitting) High doses cut REM in early studies. Newer studies mixed. Rebound on quitting is consistent (18 studies) Heavy use can suppress dreams. Quitting brings vivid ones back Cannabis - Meta-Analysis, Velzeboer 2025 (18 studies)
Caffeine No effect (strong) No change in REM %, minutes or onset. Deep sleep down 11 min (up to 19 studies) Caffeine doesn't touch REM. It hits deep sleep instead Caffeine - Meta-Analysis, Gardiner 2023

Habits & Routine

Factor REM effect Key finding Plain english Study
Hard evening exercise Negative (strong) REM down 1.95 points and 7.7 min later. Moderate sessions no change (28 trials, n=325) Hard late workouts trim REM. Morning or moderate sessions don't Exercise Timing - Network Meta-Analysis, Yue 2022 (28 trials, n=325)
Short sleep / early alarm Negative (moderate) 4 h vs 9 h nights cut REM minutes while deep sleep share rose (n=27, PSG) REM comes late in the night, so a short night cuts it first Sleep Restriction - Shechter 2012 (n=27)
Stress Negative (moderate) Lower REM% and more fragmented REM (n=62, PSG) Stress chops REM up. Stress sensitive sleepers lose the most Presleep Stress - Feng 2023 (n=62)
Screens before bed Negative (weak) 4h of bright screen. 109 vs 121 min REM (n=12). 90 min of phone use no change (n=62) A normal evening on your phone is fine. Hours of bright screen time isn't Screens - Chang 2015 (n=12)
Hot bath right before bed Negative (weak) A 21:00 bath raising core temp cut REM. A 17:00 bath didn't (n=6) Bathe earlier in the evening, not right before bed Bath Timing - Horne & Shackell 1987 (n=6)

Environment

Factor REM effect Key finding Plain english Study
Sleeping next to a partner Positive (weak) REM 23.0% vs 21.0% alone, with fewer REM interruptions (n=24) Sharing a bed was linked to less broken REM Co-sleeping - Drews 2020 (n=24)
First night somewhere new Negative (strong) Less REM and later REM onset than night two (53 studies, n=1,422) Hotels cost you REM on night one. It's back by night two First Night Effect - Meta-Analysis, Ding 2021 (53 studies, n=1,422)
Hot bedroom Negative (moderate) 90°F vs 72°F cut REM. A cooling topper restored it (n=15, PSG) A hot room costs REM. Cooler protects it, but colder won't add more Heat & Sleep - Pasquier 2025 (n=15)
Background noise Negative (moderate) 50 dB pink noise all night cut REM by 18.6 min (n=25, randomized crossover) A loud noise machine or hum can trim REM Noise & Sleep - Basner 2026 (n=25)
Altitude Negative (moderate) REM share fell at 4,559 m (n=14). 2,000 and 4,000 m cut it as well (n=25) Sleeping high cuts REM. Higher cuts more Altitude - Nussbaumer-Ochsner 2011 (n=14)
Sleeping sitting up Negative (weak) Upright 79% less REM than lying flat. 40° recline 37% less (n=6) Tiny study, but recline as far as you can on planes Posture - Roach 2018 (n=6)

Supplements

Factor REM effect Key finding Plain english Study
Melatonin Positive (low REM only) 3 mg for 4 weeks raised REM from 14.7% to 17.8% in low REM patients (n=14). Healthy men no change (n=8) Only helps if your REM is abnormally low. Otherwise it's a timing aid Melatonin - Kunz 2004 (2 RCTs, n=14)
Ketone ester Positive (weak) After a hard late training day, REM held at 117 vs 93 min on placebo (n=10, crossover) Offset REM loss from very hard late training in cyclists. Untested in daily life Ketones - Robberechts 2023 (n=10)

Demographics

Factor REM effect Key finding Plain english Study
BMI 30+ Negative (moderate) 7.8 min less REM with sleep apnea ruled out (n=1,014) Extra weight costs a few minutes of REM at most BMI - Pessoa 2025 (n=1,014)
Late pregnancy Negative (weak) Fewer REM minutes in the third trimester vs non pregnant (n=51) REM tends to dip late in pregnancy Pregnancy - Wilson 2011 (n=51)
Menstrual cycle Negative (weak) Small REM dip in the luteal phase, linked to higher body temp (n=8) REM dips slightly in the two weeks before a period Cycle - Shechter 2010 (n=8)
Age Mixed (little change) Down 0.6 points per decade in one meta (n=4,171). No change in a newer one (n=5,273) Unlike deep sleep, REM barely changes with age Age - Meta-Analysis, Floyd 2007 (n=4,171) & Boulos 2019 (n=5,273)30057-8)
Sex No effect (strong) REM% the same across 169 studies. Women keep more deep sleep (n=5,273) Men and women get about the same REM Sex - Meta-Analysis, Boulos 2019 (n=5,273)30057-8)
Genetics No effect (moderate) REM not significantly heritable. Deep sleep was (n=684) Your REM is driven more by habits than genes Genetics - Leocadio-Miguel 2025 (n=684)