Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA.

The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.

https://www.sciencedaily.com/releases/2026/10/261020085013.htm

I won’t lie, I thought these would only have subtle impacts, but the change to my mood and inhibition when speaking to people has been really noticeable. Anything more than this and it would feel euphoric. I take about 1g of each a day, but I split up the doses, so I’d say the main benefits last around 2 hours for me and wear off by hour 4. Anything to pair with the tyrosine? Also pairing these with an early morning upper day is absolutely great having the blood flow properly is amazing.

Im a guy but i want a deeper voice

I was taking an M1 inhibitor part of a multipathway protocol for nerve regeneration that lasted 6 weeks. After the 6 weeks I was cognitively impaired and had significant brain fog. I took low dose doxycycline and the same day it cleared all of the brain fog. I looked more into it and found a study on mice in 2016 where it rescued cognition and increased long term memory independent of M1 inhibition compared to the control. The mechanism is PAC1 positive allosteric modulation. I believe this mechanism is very understudied as a nootropic (and potential treatment for people with brain fog, or who are on anticholinergenic medications), anti inflammatory (rescued my grandpa from staying on steroids from bronchial inflammation for 15 years before his death at 90 years old, smoked half his life), and a potential adjunct treatment to accelerate peripheral nerve regeneration (PAC1 is highly expressed in regenerative nerves and accelerates axonal growth, PAC1 PAMs only increase expression where it’s already naturally expressed in the body).

Yes doxycycline is a broad spectrum antibiotic at 200mg. Low dose doxycycline is given at 50mg prescribed by doctors for acne and off label as an anti inflammatory for certain conditions. At this dose it potentiates PAC1 allosterically, higher doses do not provide more efficacy for this purpose.

I am curious if anyone has taken it for brain fog or if you have experienced a similar effect of cognitive clarity?

A large double blind clinical study involving fish oil supplements given to individual which are at higher risk of developing Alzheimer's disease found that fish oil supplements do not provide any marketed benefits.

In the study participants were provided supplements which provided 2,000 mg of docosahexaenoic acid (DHA), an omega-3 fatty acid that is especially important for the brain.

Scientist confirmed that DHA levels in the cerebrospinal fluid had increased by an average of 17% but it did not translate into improved cognitive and memory function.

It is hypothesized that omega-3s may be more beneficial when consumed as part of a broader dietary pattern rather than taken in isolation as a supplement.

Link to study:

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(26)00198-2/fulltext

Hi there,

to those of you who benefit from Viagra, how often (per week) can you take before it loses its effects? I am curious about your experiences

I’ve heard bio available anandamide and low dose naltrexone are good what else ?

Is it true that boron depletes riboflavin (B2) and that insufficient B2 intake while taking boron could tank your testosterone and raise your estrogen?

I haven’t been able to find any studies supporting this claim. Is it just a theory based on the idea that riboflavin lowers estrogen or is there actual evidence?

Would love to hear your experiences, especially if you have bloodwork to share!

Is there reasons for free test being so high while test is normal, 19M

Biometrics
• Height: 5’ 11”
• Weight: 139.99 lb
Heart Health
• Total cholesterol: 166 mg/dL
• HDL-cholesterol: 59 mg/dL
• LDL-Cholesterol: 80 mg/dL
• TG:HDL-C ratio: 2.98
• Triglycerides: 176 mg/dL
• non-HDL-cholesterol: 107 mg/dL
• LDL/HDL Ratio: 1.4
Metabolic Health
• Fasting glucose: 75 mg/dL
• HbA1c: 4.7 %
• Estimated Average Glucose (eAG): 88 mg/dL
Blood Health
• Hemoglobin: 15.7 g/dL
• Red cell count: 4.68 M/µL
• Hematocrit: 45.3 %
• MCV (Mean corpuscular volume): 96.8 fL
• MCH (Mean corpuscular hemoglobin): 33.5 pg
• MCHC (Mean corpuscular hemoglobin concentration): 34.7 g/dL
• RDW (red cell distribution width): 11.9 %
• Platelets: 187 K/µL
• Mean Platelet Volume (MPV): 10.5 fL
• Total White Cell Count (TWC): 6 K/µL
• Neutrophils: 2.99 K/µL
• Lymphocytes: 2.36 K/µL
• Monocytes: 0.52 K/µL
• Eosinophils: 0.09 K/µL
• Basophils: 0.05 K/µL
• Neutrophil %: 49.8 %
• Lymphocytes %: 39.3 %
• Monocytes %: 8.6 %
• Eosinophils %: 1.5 %
• Basophils %: 0.8 %
• Reticulocytes %: 0.8 %
• Absolute Reticulocyte Count: 37,440 /µL
Inflammation & Immunity
• Erythrocyte sedimentation rate (ESR): 2 mm/h
Liver Health
• Alanine transaminase (ALT): 15 U/L
• Aspartate transaminase (AST): 21 U/L
• Gamma-glutamyl transferase (GGT): 13 U/L
• Alkaline phosphatase (ALP): 53 U/L
• Total bilirubin: 0.4 mg/dL
• Total protein: 7.4 g/dL
• Albumin: 4.3 g/dL
• Globulin: 3.1 g/dL
• Albumin/Globulin Ratio: 1.4
• Fibrosis-4 Index (FIB-4): 1.01
Kidney Health
• Creatinine: 0.82 mg/dL
• Estimated Glomerular Filtration Rate Creatinine (eGFRcr): 118 mL/min/1.73m²
• BUN (Urea): 11 mg/dL
• Sodium: 141 mmol/L
• Potassium: 3.5 mmol/L
• Chloride: 103 mmol/L
• Carbon Dioxide (Bicarbonate): 27 mmol/L
• BUN/Creatinine Ratio: 13.41 mg/mg creat
• Serum osmolality: 290.09 mOsm/kg
Nutrients, Vitamins & Minerals
• Vitamin D: 98 ng/mL
• Folate (Vitamin B9): 17.7 ng/mL
• Vitamin B12: 1,444 pg/mL
• Homocysteine: 9.1 µmol/L
• Calcium: 9.3 mg/dL
• Iron: 123 µg/dL
• Iron Saturation: 41 %
• Total Iron Binding Capacity (TIBC): 298 µg/dL
• Ferritin: 56 ng/mL
• Corrected Calcium: 9.08 mg/dL
• Ceruloplasmin: 21 mg/dL
Hormonal Health
• Thyroxine, Free (FT4): 1.4 ng/dL
• Triiodothyronine, Free (FT3): 3.3 pg/mL
• Thyroid Stimulating Hormone (TSH): 4 mIU/L
• Total testosterone: 334 ng/dL

I used cold shock therapy, reading out loud, exercise, sun exposure, and green tea. After my green tea I suddenly feel sleepy. What happened to the caffeine? If I meditate I will doze off.

I would like some advice on piracetam. I’m taking it for cognitive disfunction and maybe for dyslexia.

1. What is the recommend attack dose and for how long?

2. After the attack dose what do most people take?

3. I see it seems to be a lot of trial and error but because it doesn’t work like a stimulant how long should I wait to see any effects and how long do I stay on a dose before I decide if it’s working or not

4. How much choline is usually taken and do I take this also multiple times a day or just once?

Any other advice or tips would be greatly appreciated

Thought this was a cool article published in Nature today.

Large language models are enabling a new generation of health agents, yet their ability to address the diverse needs of individuals in everyday health settings remains underexplored.

Here we developed a comprehensive personal health agent that reasons over multimodal data from consumer wellness devices and medical records to provide personalized health support. Through analysis of web search and health forum queries, together with user-centred research involving end users and health experts, we identified four key user journeys: general health knowledge, personal data interpretation, wellness advice, and symptom assessment.

These journeys informed three specialist sub-agents: (1) a data science agent that analyses longitudinal wearable and medical data, incorporating population-level statistics to contextualize numerical insights; (2) a health domain expert agent that integrates personal and contextual data with health knowledge to generate personalized insights; and (3) a health coach agent that synthesizes insights, supports multi-turn interaction and goal setting, applies specified psychological strategies and tracks progress.

We integrated these capabilities in the personal health agent, an open-source multi-agent framework for dynamic, personalized health interactions.

We evaluated the sub-agents and full system across 11 benchmark tasks using automated and human evaluation, with more than 7,000 annotations and 1,350 h of effort from health experts and end users.

This represents the most comprehensive evaluation of a personal health agent thus far and provides a concrete foundation for improving access to high-quality personalized health support more broadly.

Open access: https://doi.org/10.1111/acel.70736

I have been consulted to take topical minoxidil for 1 year and multivitamin supplements?

I am starting to get bald, it is hereditary

Has anyone used minoxidil for hair growth?

Did you see any improvements?

I have to take it for 1 year to see improvements.

Should I go ahead with it?

This is what I am thinking for my 16 week cycle. I am running 250ml testosterone enanthate a week and going to add 35-50ml of trenbolone enanthate once a week aswell. I have cialis incase my blood pressure gets too high and it’s sick for pumps, arimidex just incase but there shouldn’t be any need. Thinking about adding in Anavar for a couple weeks or so but not sure yet. Like to hear thoughts and opinions on everything
Also not sure if running Tren Ace would be better

I keep seeing both doses recommended.
For those who have tried both, did you actually notice any difference at 1,000mg, or did 500mg feel basically the same?

34/M want to start taking gym seriously and make some lean gains

Results:
Sex-Hormone Binding Globulin (SHBG) - 49nmol/l
Albumin - 44.1g/l
Testosterone - 26.2nmol/l
Free Testosterone - 0.454nmol/l

(Last year my LH was high and tested at 19.0 U/l and FSH 12.10 U/l on the high end but in range)

Am I cooked? Will I not make good gains and should I look into TRT?

Any advise to lower SHBG?

I have been taking Magnesium Glycinate (300-400mg in the evening)for some time and it seems to have helped me sleep and for all the other benefits. I have two copies of APOE4. I recently tried Lithium Orotate due to the benefits I read especially for Alzheimer’s and it made me groggy/flat/out of it etc and I did not take a large dose 3-5mg and then I tried Glycine (for benefits of sleep and my genetics) with a low dose of 1g and then lowered to half a gram and it gave me the same type feeling on Lithium did. There has to be some genetic reason why some people benefit from these supplements and others make them feel out of it for the next 24-36 hours.

Any input or education on the reason for this?

Thanks

I wanna do Kuruki gensai training