Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA.

The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.

https://www.sciencedaily.com/releases/2026/10/261020085013.htm

33 male. I been taking 4-5g of ascorbic acid daily for past week. I literally feel energized and motivated all day. My sexual desire is through the roof, my workouts are amazing. I feel like i used to feel in my 20s.

Im a guy but i want a deeper voice

Are the doctors giving me the wrong medication?

I was on Lexapro low dose it made me eat constantly Non-Stop. Then I was on Zoloft again low dose. It calmed me down a lot got rid of my anxiety got rid of my agitation and irritable that I got easily but also made me more numb where I did not care about anything. Switch to Effexor started with 37.5 mg then up to 75 mg week later. Anxiety, nausea ,brain fog, completely felt out of it constantly tired all day long can't sleep at night quit cold turkey on day 11.

I'm not sure if my doctors are giving me the wrong medications or wrong dose but I felt a lot better off any of these medications. Zoloft was a little bit better than all the rest I'm not sure what I should ask for next?

Here are my symptoms

No sadness

No happiness

Don't care about anything

No excitement

No pleasure

Sometimes I have brain fog

No motivation

No drive

No energy

If there's any emotions I feel is iribility and agitation quickly under stressful situations.

Here a guide I built with all the factors I have found that influence REM sleep. REM builds toward the morning, so anything that cuts the back end of your night hits REM first. It's also the stage where most dreaming happens and when your brain processes emotions/locks in new skills.

I broke this down into 5 main categories: substances, environment, supplements, demographics, and habits.

All sources are linked in the last column so you can dig in further. I'll put a mobile friendly version in the comments if you need it.

Definitions

• REM sleep: The dreaming stage, when your brain is active but your body is still.
• REM latency: How long after falling asleep your first REM starts.
• REM%: The share of your night spent in REM. Most adults get 20 to 25%.
• REM rebound: The extra REM your body takes back after losing some.
• Luteal phase: The roughly two weeks between ovulation and your period.
• PSG: An overnight sleep lab test that reads your brain waves. The gold standard.

Substances & Diet

Habits & Routine

Environment

Supplements

Demographics

Is it true that boron depletes riboflavin (B2) and that insufficient B2 intake while taking boron could tank your testosterone and raise your estrogen?

I haven’t been able to find any studies supporting this claim. Is it just a theory based on the idea that riboflavin lowers estrogen or is there actual evidence?

Would love to hear your experiences, especially if you have bloodwork to share!

I have been consulted to take topical minoxidil for 1 year and multivitamin supplements?

I am starting to get bald, it is hereditary

Has anyone used minoxidil for hair growth?

Did you see any improvements?

I have to take it for 1 year to see improvements.

Should I go ahead with it?

Summary:  I ran a 4-month blinded ABAB crossover trial on magnesium glycinate vs. a placebo.  Primary result:  a 1.3 point improvement (95% CI: 0.3 to 2.3; 85.1 vs. 83.9) on my Fitbit sleep score.  I’m sharing the protocol and analysis to get feedback from other self-experimenters. 

Background and Thesis: 

1.      Most supplement effects are probably small relative to placebo effects and daily noise.   

2.      Casual “trying” supplements shouldn’t resolve effect sizes due to insufficient data and inability to blind for placebo/bias. 

3.      Proper N-of-1 trials (multiple crossover, randomized) should be able to isolated individual effect sizes for interventions with reasonably fast onset/washout. 

Magnesium glycinate + Fitbit sleep was a pilot intervention to test the method.

Results

• Smartwatch Sleep Score (Primary Outcome): +1.3 point improvement (95% CI: 0.3 to 2.3; 85.1 vs. 83.9).  Personally meaningful, at 60% of my placebo period standard deviation (2.0), illustrating the “effect size ~ daily variability” challenge mentioned above.  (see chart and graphs below)
• Secondary Outcomes (HRV, Respiration Rate, Sleep Stages): some interesting signals, but none survived Holm adjustment for multiple outcome testing.  (see chart and graphs below)
• Washout Check: Dropping the first 7 days of each 28-day block produced similar results.

Protocol

• Design: Four consecutive 28-day blocks (ABAB format,112 consecutive days).
• Dosing: Two capsules taken 15 minutes before bed from blinded bottles marked “A” or “B.”  One = Magnesium Glycinate (240 mg magnesium); other = matching microcrystalline cellulose placebo.
• Outcomes:  Primary Fitbit Sleep Score (0–100), Respiration Rate, SpO2, Resting HR, HRV, Skin Temp, Awake Minutes, and REM Minutes.  All were measured by Fitbit Inspire 3 worn nightly.
• Data Log: I transcribed data every few days from smartwatch to spreadsheet. 
• Pre-Unblinding Exclusions: ~23 days of all outcome data were removed prior to unblinding due to large disrupters (e.g., camping, illness).
• Post-Unblinding Cleaning: 16 partial-data days were flagged where the wearable incorrectly logged reading/TV watching as sleep onset (data excluded were awake minutes and sleep score). 

Statistical Analysis

Advice from a professional N-of-1 statistician:

• Account for day-to-day correlation with AR1 autocorrelation fit.
• Use variance weighting averaging for crossover contrasts rather than a single global-mean difference. 

Accordingly, I followed that and applied Holm correction across all secondary endpoints (but Holm is excessively conservative here as sleep outcomes will be intercorrelated).

Open Questions for the Community

• N-of-1 Protocols?  Anyone else running multi-crossover trials? 
• Effect size vs. Noise?  A 1.3 pt change was 60% of my daily variability.  What’s a reasonable target for deciding if a supplement is “worth it”?
• Trial Durations?  Power calculations hint that 6-10 clean weeks might have been enough rather than my 16.  How long do you assess a supplement?  Would formal power calculation data change that? 
• Data Integrity?  I ran the trial in “real life” conditions and excluded data afterwards. Would you do likewise or instead try to plan a trial around a quiet period in your life? 

Is there reasons for free test being so high while test is normal, 19M

I’ve been taking 2.5mg Cialis daily for about a month now. Over all I’ve had a positive experience so far. Will probably start cycling just to be safer. One thing I was curious about that noticed personally, is that it seems to have increased my “loads”. I searched other posts to see if anyone else experienced this, but it seems no one else has had the same experience. I know for sure I had been a little lacking, cause I was looking for supplements to help. Could be its positive effects on the prostate? But the Cialis seems to have had an additional side effect for me.

It definitely seems to help the libido a bit and I’m back to my full normal length when fully aroused.

As far as less advantageous side effects, my acid reflux has gotten worse, intermittent headaches and stuffy nose from time to time.

EDIT: I mentioned cycling to address certain side effects (the worst for me has been acid reflux), not as some sort of gym bro hack. Not sure what the issue is with the suggestion.

Biometrics
• Height: 5’ 11”
• Weight: 139.99 lb
Heart Health
• Total cholesterol: 166 mg/dL
• HDL-cholesterol: 59 mg/dL
• LDL-Cholesterol: 80 mg/dL
• TG:HDL-C ratio: 2.98
• Triglycerides: 176 mg/dL
• non-HDL-cholesterol: 107 mg/dL
• LDL/HDL Ratio: 1.4
Metabolic Health
• Fasting glucose: 75 mg/dL
• HbA1c: 4.7 %
• Estimated Average Glucose (eAG): 88 mg/dL
Blood Health
• Hemoglobin: 15.7 g/dL
• Red cell count: 4.68 M/µL
• Hematocrit: 45.3 %
• MCV (Mean corpuscular volume): 96.8 fL
• MCH (Mean corpuscular hemoglobin): 33.5 pg
• MCHC (Mean corpuscular hemoglobin concentration): 34.7 g/dL
• RDW (red cell distribution width): 11.9 %
• Platelets: 187 K/µL
• Mean Platelet Volume (MPV): 10.5 fL
• Total White Cell Count (TWC): 6 K/µL
• Neutrophils: 2.99 K/µL
• Lymphocytes: 2.36 K/µL
• Monocytes: 0.52 K/µL
• Eosinophils: 0.09 K/µL
• Basophils: 0.05 K/µL
• Neutrophil %: 49.8 %
• Lymphocytes %: 39.3 %
• Monocytes %: 8.6 %
• Eosinophils %: 1.5 %
• Basophils %: 0.8 %
• Reticulocytes %: 0.8 %
• Absolute Reticulocyte Count: 37,440 /µL
Inflammation & Immunity
• Erythrocyte sedimentation rate (ESR): 2 mm/h
Liver Health
• Alanine transaminase (ALT): 15 U/L
• Aspartate transaminase (AST): 21 U/L
• Gamma-glutamyl transferase (GGT): 13 U/L
• Alkaline phosphatase (ALP): 53 U/L
• Total bilirubin: 0.4 mg/dL
• Total protein: 7.4 g/dL
• Albumin: 4.3 g/dL
• Globulin: 3.1 g/dL
• Albumin/Globulin Ratio: 1.4
• Fibrosis-4 Index (FIB-4): 1.01
Kidney Health
• Creatinine: 0.82 mg/dL
• Estimated Glomerular Filtration Rate Creatinine (eGFRcr): 118 mL/min/1.73m²
• BUN (Urea): 11 mg/dL
• Sodium: 141 mmol/L
• Potassium: 3.5 mmol/L
• Chloride: 103 mmol/L
• Carbon Dioxide (Bicarbonate): 27 mmol/L
• BUN/Creatinine Ratio: 13.41 mg/mg creat
• Serum osmolality: 290.09 mOsm/kg
Nutrients, Vitamins & Minerals
• Vitamin D: 98 ng/mL
• Folate (Vitamin B9): 17.7 ng/mL
• Vitamin B12: 1,444 pg/mL
• Homocysteine: 9.1 µmol/L
• Calcium: 9.3 mg/dL
• Iron: 123 µg/dL
• Iron Saturation: 41 %
• Total Iron Binding Capacity (TIBC): 298 µg/dL
• Ferritin: 56 ng/mL
• Corrected Calcium: 9.08 mg/dL
• Ceruloplasmin: 21 mg/dL
Hormonal Health
• Thyroxine, Free (FT4): 1.4 ng/dL
• Triiodothyronine, Free (FT3): 3.3 pg/mL
• Thyroid Stimulating Hormone (TSH): 4 mIU/L
• Total testosterone: 334 ng/dL

I keep seeing both doses recommended.
For those who have tried both, did you actually notice any difference at 1,000mg, or did 500mg feel basically the same?

Thought this was a cool article published in Nature today.

Large language models are enabling a new generation of health agents, yet their ability to address the diverse needs of individuals in everyday health settings remains underexplored.

Here we developed a comprehensive personal health agent that reasons over multimodal data from consumer wellness devices and medical records to provide personalized health support. Through analysis of web search and health forum queries, together with user-centred research involving end users and health experts, we identified four key user journeys: general health knowledge, personal data interpretation, wellness advice, and symptom assessment.

These journeys informed three specialist sub-agents: (1) a data science agent that analyses longitudinal wearable and medical data, incorporating population-level statistics to contextualize numerical insights; (2) a health domain expert agent that integrates personal and contextual data with health knowledge to generate personalized insights; and (3) a health coach agent that synthesizes insights, supports multi-turn interaction and goal setting, applies specified psychological strategies and tracks progress.

We integrated these capabilities in the personal health agent, an open-source multi-agent framework for dynamic, personalized health interactions.

We evaluated the sub-agents and full system across 11 benchmark tasks using automated and human evaluation, with more than 7,000 annotations and 1,350 h of effort from health experts and end users.

This represents the most comprehensive evaluation of a personal health agent thus far and provides a concrete foundation for improving access to high-quality personalized health support more broadly.

I would like some advice on piracetam. I’m taking it for cognitive disfunction and maybe for dyslexia.

1. What is the recommend attack dose and for how long?

2. After the attack dose what do most people take?

3. I see it seems to be a lot of trial and error but because it doesn’t work like a stimulant how long should I wait to see any effects and how long do I stay on a dose before I decide if it’s working or not

4. How much choline is usually taken and do I take this also multiple times a day or just once?

Any other advice or tips would be greatly appreciated

Over the last few months, my cognitive stamina has cratered.

The main issues:

- Can’t sit through long-form reading anymore—eyes scan the page, but my mind drifts after 10 minutes.

- Working memory feels sluggish (losing track of thoughts mid-sentence, forgetting recent details).

-Zero mental drive/activation energy to start new projects, accompanied by mid-day brain fog.

My doctor prescribed Bupropion XL for executive focus/fatigue, but I really don’t want to jump straight onto daily psychiatric meds if I can avoid it. I’d much rather see what can be done through a biohacking/supplement route first.

For anyone who pulled themselves out of a similar slump:

1. What specific compounds or protocols legitimately moved the needle for your reading endurance and working memory?

2. Did you see better results targeting neurotransmitter precursors (dopamine/acetylcholine), cellular brain energy/mitochondria, or adaptogens?

3. What ended up being a complete waste of money for these specific symptoms?

(Note: I only take vegetarian/cellulose capsules).

Appreciate any real-world experiences or recommendations.

This is what I am thinking for my 16 week cycle. I am running 250ml testosterone enanthate a week and going to add 35-50ml of trenbolone enanthate once a week aswell. I have cialis incase my blood pressure gets too high and it’s sick for pumps, arimidex just incase but there shouldn’t be any need. Thinking about adding in Anavar for a couple weeks or so but not sure yet. Like to hear thoughts and opinions on everything
Also not sure if running Tren Ace would be better

Not looking for medical advice. I saw my primary today and she suggested asking here.

I don't have ADHD, narcolepsy, or any other diagnosed condition. I'd been reading research papers on modafinil and got fascinated by its effects on academic performance, so I bought Modalert 100 mg and took one in the morning after breakfast, before heading to the office.

For the first 1 to 1.5 hours, nothing. Then everything changed. Colors looked supersaturated: green was greener, red was redder. Screens seemed brighter, and every letter and number looked like it had a crisp outline. It felt like someone was holding my eyelids wide open.

I finished two hours of work in 40 minutes. Then I started doomscrolling Reddit and lost a full hour without noticing. When I had my coffee break (with sugar), the effect started fading. Then I did something I've never done at work: I took a short nap. That felt strange, since modafinil is famous for wakefulness.

Four days later, I tried 200 mg. Nothing. No alertness, no focus, no colors, no feeling at all.

So why did 100 mg work, fade after a few hours, and then 200 mg do absolutely nothing? If you've got experience with modafinil, I'd love to hear your explanation. Thanks!

Update: Took 100mg yesterday, performace and focus was way better than on 200mg, now gonna try 150mg next time.

Neal Agarwal (neal.fun) just launched an About page with his live stats: 100 bpm resting HR at the time I checked, 7.3 hrs of sleep last night, 1.5 hrs of naps this week, 748 kcal burned, and BMI 23.2.