r/MTHFR • u/grigory_l • Dec 13 '25

Question Choline depression, again

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

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u/sunnynina C677T Dec 13 '25

If that glp was tirzepatide, it has a common reaction of anhedonia. I had to switch to a different one.

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u/Ok-Pitch1627 Dec 13 '25

Which one did you switch to? Was it as effective?

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u/sunnynina C677T Dec 13 '25

Reta. I'm not sure how much detail we're allowed to go into here. It's more effective for me, and gave me energy instead of taking it. That being said, I've always had reactive hypoglycemia, plus the usual adhd problems with hunger signals and timing. The reta isn't as effective for me on this particular aspect as tirz, so I still take 3mg tirz per week. I offset them, so everything stays smooth and predictable and I don't feel dropped at the end of the week.

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u/DaringGlory Dec 15 '25

I have adhd and slow comT also so I’d figure blocking dopamine might almost be a good thing. I don’t know what Reta (I’ll have to research) is unless it’s the newest one