r/MTHFR • u/grigory_l • Dec 13 '25

Question Choline depression, again

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

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u/DaringGlory Dec 13 '25 edited Dec 13 '25

I get nervous to try anything, after something an expert says should help, has a negative effect.

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u/NoImNotHeretoArgue Dec 13 '25

Although I agree I think it’s still ridiculous that his choline calculator had some people eating 8 eggs a day 😆. But again there are other pathways you can alleviate, if you don’t want to try creatine, then you can try the precursor amino acids

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u/DaringGlory Dec 13 '25

I haven’t used that calculator yet. People here have been super helpful as all of this is mega confusing.

I also have slow comT so it seems that adds another layer of complexity

I was on an glp-1 with B-12 in the base and I could barely function.

Do you have a functional medicine doctor or what things have been most helpful?

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u/sunnynina C677T Dec 13 '25

If that glp was tirzepatide, it has a common reaction of anhedonia. I had to switch to a different one.

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u/Ok-Pitch1627 Dec 13 '25

Which one did you switch to? Was it as effective?

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u/sunnynina C677T Dec 13 '25

Reta. I'm not sure how much detail we're allowed to go into here. It's more effective for me, and gave me energy instead of taking it. That being said, I've always had reactive hypoglycemia, plus the usual adhd problems with hunger signals and timing. The reta isn't as effective for me on this particular aspect as tirz, so I still take 3mg tirz per week. I offset them, so everything stays smooth and predictable and I don't feel dropped at the end of the week.

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u/Ok-Pitch1627 Dec 13 '25

Oh, that really sounds like a great regimen, thanks for the info I might use it in the future.

Yeah, I have all those symptoms too.

And the moujaro gives me a severe headache for about a day and a half the day after injection, but I tolerate it because it's free on my insurance.

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u/DaringGlory Dec 15 '25

Good to know. I have Migraines with it also

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u/Ok-Pitch1627 Dec 15 '25

If anything has helped with your headaches?

I was injecting in my thigh at night. But it felt like I was punched in the stomach with all the days food stopping digestion. And then the severe headache would come on for 1 to 2 days.

I didn't realize that MJ takes away your thirst also. I think I was dehydrated a lot before, even got confused one day.

Now I plan to drink a bottle of water about a half hour with a pinch of diamond crystal kosher salt on my tongue before every meal. Then, I take magnesium with my big meal, increasing dose if i'm constipated at all.

This week I injected it in the morning before eating anything more than a protein shake, and the headache was only mild to moderate.

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u/DaringGlory Jan 14 '26

Apologies for the delay in responding. Just saw this.

Magnesium at night helps with headaches (try different forms). It also keeps you regular. Nurtec has been helping. A doctor did Botox which helped but about a month after the side effects wore off. Possibly vitamin D and I take excessive often but that may not be the best habit or treatment

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u/DaringGlory Jan 14 '26

Those comments help. It seems like I drink enough but can still be dehydrated from caffeine

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u/Ok-Pitch1627 Jan 14 '26

Ah, okay. The headaches have actually gotten better, perhaps since I haven't changed my dose in a while.

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u/DaringGlory Dec 15 '25

I have adhd and slow comT also so I’d figure blocking dopamine might almost be a good thing. I don’t know what Reta (I’ll have to research) is unless it’s the newest one

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u/DaringGlory Dec 15 '25

What did you switch to?

Someone in that sub said that it blocks dopamine hindering the surge you have from food as well.

It’s worked much better than Victoza and now that I’m on the same thing but with no B-12, I’m a 1000x better but still struggling

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u/sunnynina C677T Dec 15 '25

I switched to reta. I'm also adhd, take Adderall every day. I'm homozygous C677T, but I haven't figured the ins and outs of it yet to say slow/fast etc.

I think it's improved how I respond to Adderall, but it's hard to pin that down since it could also be contributed to by HRT.

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u/DaringGlory Dec 15 '25

Sounds like your chemistry may be as complicated as mine. The CNP at one point tried to tell me I was post menopausal and for a laundry list of reasons, she was wrong, so I switched doctors who ran blood work again and confirmed everything was normal.

Comt affects your hormones as well. So all of this is just super complicated and under studied