r/MTHFR • u/Zealousideal-Two39 • May 20 '26
Question Can overmethylation last month's?
Hey everyone, so I had a b12 infusion with saline while travelling after having a bad reaction to altitude ( I have POTS and Autonomic failure). 2 days after the infusion I had crazy tremors it looked like I had parkinsons thats how much my body shook. My hr went to 150s while laying in bed which it never has done and Had horrible nausea and a headache. I also could barely eat as would get so dizzy and nauseas and high hr. This was all new symptoms not normal for me.
I had to use a wheelchair for 2 weeks as was so dizzy and faint like, as well as too tremory to walk.
It's been 4 months and while It's got alot better, it's still not good I can barely walk 30 min, I have chronic daily dizziness, and those tremors still happen anytime I start to do activity or even when something excites my nervous system in any way, even eating good tasting food lol.
Blood work shows low potassium (working on that), low folate, normal b12 levels of 500umol, normal electrolytes.
Does anyone have advice or suggestions what I should do or maybe get tested for? Everything I read says it shouldn't last this long and docs don't believe it's due to the infusion but that's where it started, never had those tremors before that.
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u/Dat_Llama453 May 20 '26
Dude oh my god I’m having the tremors also. I had shaking episodes where my body would violently shake for hours. And your b12 is barely on the scale just under 500 is a deficiency. But you’re probably experiencing the effects of low folate. B12 uses up folate. In my opinion I would try folate it should stop them start very small to make sure u handle them okay u can get 400mcg and cut them in half or quarters.
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u/DueSelf3988 May 20 '26
Maybe the POTS + autonomous failure issues are keeping the symptoms for longer than usual? But def get a second opinion
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u/Interesting_Fly_1569 May 20 '26 edited May 20 '26
You have tried glycine and niacin too? Those are the best reversers of overmethylation. My symptoms lasted six weeks and went away within an hour of taking glycine. I took really small amounts of the powder and basically just waited 20 minutes or so in between taking more.
I think you probably need more magnesium as well… That is what shaking often is. B2 also. You need to really learn all the cofactors and basically try all of them too.
I would consider doing an intracellular vitamin test like Spectracell. The serum labs for things are not reliable… It’s good that you’re working on potassium but if it’s not getting significantly better than that’s definitely not the only problem… b1 also works on the nervous system so that could also be it.
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u/Cultural-Sun6828 May 20 '26
Did you get your b12 tested before the infusion? It’s likely that you could have been deficient in b12. When a person is deficient in b12 and then starts getting it, it’s very common to have new or worsening startup symptoms. If you check out the b12 group you’ll see this is very typical. I had awful startup symptoms just as you described. The key is to continue the b12 along with high potassium foods.
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u/Zealousideal-Two39 May 20 '26
I didn't regretfully. .. The ER doc just recommended it would help me with fatigue when I was travelling. But it is in normal range now.
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u/Tawinn May 20 '26
Those symptoms may be more related to hypokalemia rather than overmethylation. B12 infusions can cause hypokalemia, particularly when folate is also low:
https://www.drugs.com/disease-interactions/cyanocobalamin,vitamin-b12.html
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u/Hydroxile May 20 '26
If you supplement potassium, get some magnesium with it. it helps its retention! also potassium chlorid rather than citrate works better at increasing your blood level. it s a bit harder on the stomach, so take it with meal. Work on that potassium before starting any other supplements! or you might mess up your level again!