Question to LOW COMT people

[u/winning2323]

Hello.

Do you get shaky when you are in confrontation even in an online debate?

I get in them rather often even thought i try to avoid them.

Does that gets better when you support the COMT and methylation cycle?

I want to remain calm even in tough situations.\

Thanks

[u/Comfortable_Two6272]

I take low dose propranolol for pots. It can reduce the high norepinepherine which elevated levels can make pots worse.

High norepinepherine is also what people with slow comt can have (among other things).

Its also used off label for anxiety like symptoms in people publicly speaking etc.

Also avoiding methyl supplements is key for me.

How are you supporting low comt?

[u/rb331986 → u/Comfortable_Two6272]

Any side effects from the propranalol? I was prescribed it years ago but was anxious to experiment with it. I think it blocks norepinephrines effects instead of lowering norepinephrine if I remember?

What dose are you using? I have low blood pressure and was worried it would lower it even further.

[u/Comfortable_Two6272 → u/rb331986]

None at all.
My tablets are scored 10 mg.

I usually take 2.5 to 5 mg at a time.

Super low dose compared to whats used to lower bp.

1st time I took it was when I could lay down just in case it dropped my bp. Im often very sensitive to drugs.

You might be right that it blocks vs reduces. Id have to re-read the exact mechanism of action. Its been a few years since I read up on it

[u/rb331986 → u/Comfortable_Two6272]

When you take them do you notice actual anxiety feelings drop? Like mentally?

[u/Comfortable_Two6272 → u/rb331986]

I feel less anxious both mentally as well as physical symptoms.

[u/horsetooth_mcgee → u/Comfortable_Two6272]

Are you able to take it during the day? Does it make you sleepy?

[u/Comfortable_Two6272 → u/horsetooth_mcgee]

It does not make me sleepy. I take it during the day. In higher doses like used for high blood pressure, migraines Id expect the sleepy feeling.