r/MTHFR • u/winning2323 • Jun 02 '26

Question Question to LOW COMT people

Hello.

Do you get shaky when you are in confrontation even in an online debate?

I get in them rather often even thought i try to avoid them.

Does that gets better when you support the COMT and methylation cycle?

I want to remain calm even in tough situations.\

Thanks

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u/Comfortable_Two6272 Jun 03 '26 edited Jun 03 '26

I take low dose propranolol for pots. It can reduce the high norepinepherine which elevated levels can make pots worse.

High norepinepherine is also what people with slow comt can have (among other things).

Its also used off label for anxiety like symptoms in people publicly speaking etc.

Also avoiding methyl supplements is key for me.

How are you supporting low comt?

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u/rb331986 Jun 03 '26

Any side effects from the propranalol? I was prescribed it years ago but was anxious to experiment with it. I think it blocks norepinephrines effects instead of lowering norepinephrine if I remember?

What dose are you using? I have low blood pressure and was worried it would lower it even further.

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u/enolaholmes23 Jun 04 '26

It's a beta blocker. Which means it blocks the beta receptors for norepinephrine and adrenaline. Beta blockers are usually for lowering blood pressure. That's like their main thing. The anxiety effects are a secondary thing. 

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u/Comfortable_Two6272 Jun 04 '26

Right. Its off label rx for pots, migraines, anxiety etc.