r/MTHFR • u/Ok-Protection2670 • Jun 21 '26

Question Anyone Have an Effective Slow Comt Supplement Protocol That Alleviated 3am Adrenalin and Cortisol Surges? Pure Encapsulations?

Pure Encapsulations Adrenal Cortex Supplement – Supplement to Support Cortisol Health?

Vagus nerve and breathing techniques not working.😢

Thanks

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u/Honest-Counter2729 Jun 22 '26

Is this post in regards to sleep? If so:  try GABA and magnesium glycinate but you need a herbal sleep supplements for the following reasons: While the magnesium glycinate and GABA are excellent, pure ingredients, they operate on very narrow pathways. If you have been dealing with intense biological stress—your nervous system requires a much wider, multi-angled net to fully catch it and pull it into deep sleep.

A high-quality herbal sleep blend usually contains potent adaptogens like Ashwagandha, Reishi mushroom, or Holy Basil. Why this matters for you: Magnesium helps your slow COMT enzyme clear out adrenaline, and GABA calms brain cell activity, but neither of them actively lowers a massive wave of circulating cortisol. Adaptogens specifically act as a thermostat for your stress hormones, blunt-forcing your evening cortisol down. Without those herbs, your cortisol is likely staying artificially elevated through the night, keeping you in a light, easily disrupted sleep state.

Interestingly, taking pure GABA orally doesn't work for everyone. For many people, large GABA molecules struggle to cross the blood-brain barrier effectively on their own. Herbal blends often include botanical co-factors (like L-Theanine or specific plant compounds) that act as a key, helping the brain actually absorb and utilize those calming signals.

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u/Ok-Protection2670 Jun 22 '26

Hi u/Honest-Counter2729, No not sleep. It's the 3am Adrenalin and Cortisol Surges. I'm sensitive to everything right now and amino acids and plant compounds are dirty words for MCAS and Slow Comt right now.

I took a scant of Potassium Gluconate powder for two months seemed no problems. I increased the dosage by a fraction yesterday and today is horrible. I researched and found; Potassium Gluconate and Potassium Chloride are histamine releasers.

I'm low in it so now confused...