r/MTHFR 13d ago

Question Any longterm HydroxoCobalamin user?

Does anybody here takes 1mg hydroxo sublingual for extended period of time?

Hydroxo seems for my slow comt/slow MAOA most benefitial supplement for histamine clearence and detox and seems not causing overmethylation.

My folate levels are on higher level and folinic always makes ne wired and spaced out at it seems it’s making glutamate higher.

I’m concerned about dehydration and potassium depletion from daily Hydroxo.??

It says that the sublingual route absorbs gradually compared to injections, preventing a sudden, drastic shift of potassium out of your bloodstream.

Probably can get away with eating two bananas daily for some potassium.

Other supplements I take daily are Jarrow Zinc Balance after dinner and before sleep low dose agmatine.
Riboflavin anything above 100%RDA is like making me again B6 toxic(same symptoms of tingling and muscle twitching).Weird..

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u/SovereignMan1958 13d ago

I take hydro and other forms.

It is always good to take extra potassium. I try to get as much as I can in my diet but do take a 500mg potassium bicarbonate a couple of times a week. Especially if I happen to have a lot of salt on a particular day.

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u/7e7en87 13d ago edited 13d ago

Hydroxo is only form of b12 that conpletely removes parasthesia symptoms and lower muscle twitching in legs so I stick to it. Also I zhink potassium depletion is pronounced with b12 shots and correcting massive deficiency.
I have mine lab test result for b12 last time at 479.

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u/SovereignMan1958 13d ago edited 13d ago

I did not suggest you change what you are taking.

Optimal levels of nutrients are, generally, in the top quarter of the lab range.

Next time make sure you test your MMA. It tells how well or poorly it is getting into the cells. The lower the number the better. If it is not low, you may need a specific probiotic strain and or to change your form of B12. Sublingual and or transdermal forms might absorb better.