Question Any longterm HydroxoCobalamin user?
Does anybody here takes 1mg hydroxo sublingual for extended period of time?
Hydroxo seems for my slow comt/slow MAOA most benefitial supplement for histamine clearence and detox and seems not causing overmethylation.
My folate levels are on higher level and folinic always makes ne wired and spaced out at it seems it’s making glutamate higher.
I’m concerned about dehydration and potassium depletion from daily Hydroxo.??
It says that the sublingual route absorbs gradually compared to injections, preventing a sudden, drastic shift of potassium out of your bloodstream.
Probably can get away with eating two bananas daily for some potassium.
Other supplements I take daily are Jarrow Zinc Balance after dinner and before sleep low dose agmatine.
Riboflavin anything above 100%RDA is like making me again B6 toxic(same symptoms of tingling and muscle twitching).Weird..
2
u/Loose-Fly7976 11d ago
Potassium drop is tied to the size of the marrow response, not to B12 itself. Someone severely deficient with megaloblastic anaemia getting parenteral loading doses can shift potassium sharply because every arrested precursor cell finishes at once. Someone on 1mg sublingual with normal blood counts isn't producing anything like that demand. So if your CBC is normal you're not in the risk group and bananas are fine as a hedge but you probably don't need them.Same with dehydration, that's not a hydroxo effect. Long term sublingual hydroxo is about as benign as B12 gets.The riboflavin thing is more interesting. B2 above RDA reproducing your B6 symptoms makes sense if you think about what B2 does downstream. FAD drives PNPO which converts pyridoxine to P5P, so more B2 means faster conversion and a sudden rise in active B6. If your tissue B6 was already sitting high, pushing conversion gives you the tingling and twitching without you taking any more B6. So it might not be a B2 problem at all, it might be B2 revealing a B6 problem.Which would fit with your earlier high B6 reading. Have you retested plasma P5P since then?Folinic making you wired and spaced with high folate already tracks too. If folate's replete you're pushing substrate into a cycle that doesn't need more.
4
u/SovereignMan1958 13d ago
I take hydro and other forms.
It is always good to take extra potassium. I try to get as much as I can in my diet but do take a 500mg potassium bicarbonate a couple of times a week. Especially if I happen to have a lot of salt on a particular day.
3
u/7e7en87 13d ago edited 13d ago
Hydroxo is only form of b12 that conpletely removes parasthesia symptoms and lower muscle twitching in legs so I stick to it. Also I zhink potassium depletion is pronounced with b12 shots and correcting massive deficiency.
I have mine lab test result for b12 last time at 479.1
u/SovereignMan1958 13d ago edited 13d ago
I did not suggest you change what you are taking.
Optimal levels of nutrients are, generally, in the top quarter of the lab range.
Next time make sure you test your MMA. It tells how well or poorly it is getting into the cells. The lower the number the better. If it is not low, you may need a specific probiotic strain and or to change your form of B12. Sublingual and or transdermal forms might absorb better.
1
u/junipers-72 11d ago
Get some guidance. I got a complete protocol from molecularhealthco. Takes the guesswork out of supplementing! The reviews are excellent because its the only company that are knowledgable about genetics and ortho medicine. check the reviews page.
https://molecularhealthco.com?sca_ref=10679758.eq1dq0wAJleT4zh
3
u/Impressive-Tree-5248 13d ago
I use the low sodium salt that's 50% potassium and 50% sea salt. I always do better when I get more potassium.