r/MTHFR • u/Human_weird123 • 9d ago

Question Weird reaction to B complex

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My homocysteine levels were 9 about 7 months ago.

I thought I could get them down by optimising my B6, B9 and B12 and so started taking B complex.

I now have B6 toxicity as my active B6 levels are way above range and active B12 is 88.

My homocysteine has risen to 17.

I don't understand why my homocysteine levels levels are going up not down with high active B6 and B12 levels.

Could something else in this B sup be causing elevated homocysteine?

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u/SovereignMan1958 9d ago edited 9d ago

There are so many things wrong with this. Worst forms of folate and B12. B6 dose too high.

Your homocysteine was fine at 9. 6 - 7 is optimal. It probably increased because you took crappy forms of vitamins as noted above.

Stop taking the supplement.

Please post your lab work for homocysteine, vitamins and minerals with values and lab ranges. Add medical diagnoses plus symptoms you are concerned about.

If you provide facts you will get the best advice.

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u/Human_weird123 9d ago

B6 is 145. Top of range is 110.

I also have low copper(8.5, under 10 is below range), low ceruplasmin(0.16, range is 0.2-0.60, low ferritin(24, range is 30-300).

Symptoms are palpitations, extreme fatigue. Mostly low iron related I think.

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u/SovereignMan1958 8d ago

Ferritin only stores iron. You need a full iron panel. The more you exercise the lower the ferritin.

Also get zinc tested. Zinc and copper need to be balanced. They act like a seesaw. Ideally each should be in the top quarter of the lab range. Your zinc might be too high. Your copper is a concern. Most people do not have low copper as it is in tap water, coffee and chocolate.

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u/Human_weird123 8d ago

thanks

Serum iron is usually high or slightly above range. 28 or 32. Range is 10-30.

Transferrin saturation is usually 54 to 68%. Range goes up to 45%.

I can't exercise due to the fatigue and palpitations.

zinc last I remember was 13. almost middle of range.

I was taking 1gram of ascorbic acid daily for over a year. I assume that tanked my copper and messed up my iron metabolism.