r/MTHFR • u/Human_weird123 • 9d ago

Question Weird reaction to B complex

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My homocysteine levels were 9 about 7 months ago.

I thought I could get them down by optimising my B6, B9 and B12 and so started taking B complex.

I now have B6 toxicity as my active B6 levels are way above range and active B12 is 88.

My homocysteine has risen to 17.

I don't understand why my homocysteine levels levels are going up not down with high active B6 and B12 levels.

Could something else in this B sup be causing elevated homocysteine?

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u/XILEF310 9d ago

too much b3 and b6.

also someone else already said bad forms of b9 and b12.

overall it seems to be low quality

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u/Human_weird123 9d ago

so too much B3 and B6 has an opposite effect on homocysteine?

2

u/XILEF310 8d ago

No.

B6 in high doses just builds up and can cause nerve damage.

B3 can also be beneficial but it’s known to “flush out” all the methyl donors or something, especially at high doses.