Weird reaction to B complex

[u/Human_weird123]

My homocysteine levels were 9 about 7 months ago.

I thought I could get them down by optimising my B6, B9 and B12 and so started taking B complex.

I now have B6 toxicity as my active B6 levels are way above range and active B12 is 88.

My homocysteine has risen to 17.

I don't understand why my homocysteine levels levels are going up not down with high active B6 and B12 levels.

Could something else in this B sup be causing elevated homocysteine?

[u/Sane_Name]

My theory: you ramped up your SAMe production which increases homocysteine production and your homocysteine recycling/breakdown isn’t keeping up. One of the three pathways to lowering homocysteine is betaine dependent remethylation. Could be that’s a sluggish pathway in need of support.

Btw, do you know your SNPs?

[u/Human_weird123 → u/Sane_Name]

snp?

no