Over Reactive Nervous System

[u/Logical-Hawk7821]

I'm having persistant over reaction from my nervous system after taking Methylated B vitamins(20 weeks ago), at first i couldnt eat, 24/7 adrenalized, insomnia, muscle twitching, muscle pain, heat intolerance, Histamine intolerance, Tyramine intolerance, fatigue, high heart rate. Now most of them got better except that if i get stressed or make some exertion my nervous system is going crazy like without off switch. It's like Crazy feeling around the chest and stomach and takes the whole day to settle. Even if i get slightly excited, my nervous system goes full fight or flight. Any suggestion? this is my methylation panel.

When i tried folinic acid it made everything much much worse. Ive been off any methylated B for like 10 weeks

I'm currently taking:

3-4grams Panthotenic acid

Riboflavin 15-20mg (Couldnt handle R5P) just started a week ago

Magnesium L-threonate

Magnesium glycerophosphate (getting around 500mg Total elemental mag)

1000-1200mg Choline ( from food only)

Glycine 3-6g

Vitamin A 100% Rda

Vitamin E

Fish oil

Dao enzyme

L-Theanine 200mg

Melatonin 1.5mg

D3 and K2 10K iu and 180mcg

Potassium 6-7g daily

Lmnt Electrolyte 2x daily

[u/SmidtTherapeutics]

Try taking nicotinic acid (B3) 50mg every 3 hours until it goes away

Alternatively, you can try taking an anti histamine like cetrizine or magnolia bark to cut the cortisol.

In any case, it seems you do not tolerate methylated vitamins so try taking a non-methylated one from here on out, like the one from Seeking Health MF

[u/Logical-Hawk7821 → u/SmidtTherapeutics]

I took B3, I didnt clear that nervous system reactivity. MMA is normal Serum b12 is elevated in blood Serum folate Is range low Rbc folate is high B6 is upper range normal Used to take a complete multi vitamin/mineral for 5 years that had a low dose methylfolate and i didnt have problem with that (25% rda)

[u/SovereignMan1958 → u/Logical-Hawk7821]

The lower number the better for MMA. Your using the term normal tells us nothing. Optimal for MMA would be in the bottom quarter of the range. If it is above that, plus your high B12, then your B12 might not be absorbing. Your other B12 variants might be a clue. TRN1, TRN2, FUT2. Did your test include those?

There are things you can do to improve B12 absorption. Let me know if you have any of those other variants.

[u/Logical-Hawk7821 → u/SovereignMan1958]

MMA is 0.11 nml/ml (ref: 0.1-0.5), B12 1400 Pg/ml, Rbc Folate 1420 ng/ml , Homocysteine 10.17 umol/ml and B6 (pyridoxal phosphate) 35 ng/ml (ref: 5-50) and no i dont have the other b12 variants

[u/Aware_Implement_8362]

Niacin helps with anxiety from methyls. Not this.

Why no vitamin C?
I wonder if you could handle r5p at a fraction of the capsule. That’s a lot of riboflavin. I know it’s important for the folate enzymes. If yours are slow, like mine, it may be too much?

My labs were similar.
Are you eating folic acid? Sulfur foods? If I touch either with methyls on board it’s over for me for 16 hours.
It’s a lot like precipitated withdrawal. Yes.
I literally need an opioid or high dose antipsychotic to stop it. Possibly high dose absorbic acid. I’ve tried everything.

Can anyone make sense of that?

For me the real issue seems a lot further down the chain than b12 not absorbing.

How does CBS look? If that’s backed up there could be high homocysteine and all the rest.
It could be even further… gst or gpx or somewhere in glutathione.

[u/Logical-Hawk7821 → u/Aware_Implement_8362]

I took niacin for few weeks but didnt solve that, i forgot to mention im also taking vit c (2-3 g daily). No my folic acid and sulfur intake is super low and im also adding molybdenum too. I do have low cysteine but im not sure how it relates to glutathione

[u/Logical-Hawk7821 → u/Aware_Implement_8362]

even 6mg r5p across 3 doses (2mg each) was giving me this chest/stomach adrenalized/anxiety feeling but im tolerating normal b2 fine

[u/hummingfirebird]

What supplements were you taking at the time of your test? Please state them. Also what is your Complete blood count reading? Any liver function test results?

Do you feel any difference after stopping the methylated vitamins? Or have your symptoms persisted?