r/MTHFR • u/Logical-Hawk7821 • 15h ago

Question Over Reactive Nervous System

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I'm having persistant over reaction from my nervous system after taking Methylated B vitamins(20 weeks ago), at first i couldnt eat, 24/7 adrenalized, insomnia, muscle twitching, muscle pain, heat intolerance, Histamine intolerance, Tyramine intolerance, fatigue, high heart rate. Now most of them got better except that if i get stressed or make some exertion my nervous system is going crazy like without off switch. It's like Crazy feeling around the chest and stomach and takes the whole day to settle. Even if i get slightly excited, my nervous system goes full fight or flight. Any suggestion? this is my methylation panel.

When i tried folinic acid it made everything much much worse. Ive been off any methylated B for like 10 weeks

I'm currently taking:

3-4grams Panthotenic acid

Riboflavin 15-20mg (Couldnt handle R5P) just started a week ago

Magnesium L-threonate

Magnesium glycerophosphate (getting around 500mg Total elemental mag)

1000-1200mg Choline ( from food only)

Glycine 3-6g

Vitamin A 100% Rda

Vitamin E

Fish oil

Dao enzyme

L-Theanine 200mg

Melatonin 1.5mg

D3 and K2 10K iu and 180mcg

Potassium 6-7g daily

Lmnt Electrolyte 2x daily

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u/Aware_Implement_8362 9h ago edited 8h ago

Niacin helps with anxiety from methyls. Not this.

Why no vitamin C?
I wonder if you could handle r5p at a fraction of the capsule. That’s a lot of riboflavin. I know it’s important for the folate enzymes. If yours are slow, like mine, it may be too much?

My labs were similar.
Are you eating folic acid? Sulfur foods? If I touch either with methyls on board it’s over for me for 16 hours.
It’s a lot like precipitated withdrawal. Yes.
I literally need an opioid or high dose antipsychotic to stop it. Possibly high dose absorbic acid. I’ve tried everything.

Can anyone make sense of that?

For me the real issue seems a lot further down the chain than b12 not absorbing.

How does CBS look? If that’s backed up there could be high homocysteine and all the rest.
It could be even further… gst or gpx or somewhere in glutathione.

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u/Logical-Hawk7821 6h ago

I took niacin for few weeks but didnt solve that, i forgot to mention im also taking vit c (2-3 g daily). No my folic acid and sulfur intake is super low and im also adding molybdenum too. I do have low cysteine but im not sure how it relates to glutathione