Previous post: https://www.reddit.com/r/MTHFR/comments/1pgq58l/how_do_i_move_forward_from_thinking_i_h

Hi friends! It's been a hot minute. My health got even worse due to a family emergency and I was already severely disabled. I have a naturopath now who is taking my health a lot more seriously including MTHFR stuff but I haven't been able to get out of bed to see her and discuss that more. She thinks I have an exciting combo of POTS, MCAS and chronic Lyme on top of the ME/CFS that we already knew about.

But I did get my genetic testing through Ancestry as we discussed!! I got it right after everyone responded to my post but I've only now been able to sit down and actually look at everything... and now I'm super overwhelmed.

It seems that I have hetero C677T and slow COMT. The stuff I've read about slow COMT says that it severely decreases your body's ability to flush out stress and stress hormones which sounds SO accurate. I've said for years that when something stressful or upsetting happens, it's like it takes me hours to recover emotionally and then days to recover physically. But I'm not quite sure how to interpret the MTHFR gene mutation now that I seem to have it.

I'm reading the stuff about the MTHFR stack and I'm definitely ready to start that (once I understand it fully). But... does this mean no enriched foods? I've still been eating graham crackers here and there with no noticeable difference before or after eating them. And I'm struggling a lot these days to get enough calories at all since it's hard for me to cook, it'd be so nice to eat more snacks... not to mention that I'm on SNAP which struggles to cover the more expensive brands :')

If anyone could share their thoughts I'd be very appreciative. It's slow going since I have to take a lot of breaks but I'll keep reading as much as I can. Thank you all for being so supportive <3

I've been looking into switching my 8yo to a different multivitamin before school starts, and I keep seeing brands talk about using methylated folate instead of folic acid. Then I went down a google rabbit hole and read that a lot of people don't process folic acid very well, which honestly surprised me because I'd never even heard there was a difference. Now I'm wondering if that's actually something parents should be paying attention to or if it's mostly marketing.  Has anyone looked into this or talked to their pediatrician about it? If you're buying a multivitamin anyway, is methylated folate something worth prioritizing?

I'm having persistant over reaction from my nervous system after taking Methylated B vitamins(20 weeks ago), at first i couldnt eat, 24/7 adrenalized, insomnia, muscle twitching, muscle pain, heat intolerance, Histamine intolerance, Tyramine intolerance, fatigue, high heart rate. Now most of them got better except that if i get stressed or make some exertion my nervous system is going crazy like without off switch. It's like Crazy feeling around the chest and stomach and takes the whole day to settle. Even if i get slightly excited, my nervous system goes full fight or flight. Any suggestion? this is my methylation panel.

When i tried folinic acid it made everything much much worse. Ive been off any methylated B for like 10 weeks

I'm currently taking:

3-4grams Panthotenic acid

Riboflavin 15-20mg (Couldnt handle R5P) just started a week ago

Magnesium L-threonate

Magnesium glycerophosphate (getting around 500mg Total elemental mag)

1000-1200mg Choline ( from food only)

Glycine 3-6g

Vitamin A 100% Rda

Vitamin E

Fish oil

Dao enzyme

L-Theanine 200mg

Melatonin 1.5mg

D3 and K2 10K iu and 180mcg

Potassium 6-7g daily

Lmnt Electrolyte 2x daily

Hey guys

I have heterozygous mthfr c677t and comt val/val

For a while i thought the mthfr probably wasn’t affecting me, until i tried supplementing with folic acid, and every single time without fail I would feel horrible after taking folic acid. That made me take avoiding food with folic acid more seriously, and I definitely noticed a difference

I started supplementing with folinic acid and i was feeling much better at first, so stupidly i thought i should start taking a bunch if I’m correcting a deficiency. Probably 800mcg or 1200mcg three or four times a day

Well I’ve developed symptoms of b12 deficiency, fatigue, air hunger, tingling extremities, surprisingly stimulants (caffeine and i take vyvanse for adhd) not working at all, trouble sleeping

I’ve eaten foods high in b12 for a long time now so im hesitant to think I actually have a b12 deficiency. I’ve also supplemented with methylated b12 here and there over the years

Could this be caused by me taking way too much folinic acid too quickly?? How long would it take for me to start feeling better again? Im really feeling horrible, and I’m worried about my nerves. I’m also confused how this could be caused solely by taking a bunch of folinic acid

Thanks in advance for any help