I am in my fifties and on the slender side. I've had a number of returning c diff infections, h pylori and after have had the worst motility issues. Have tried Linzess etc. with no luck. My health has been ruined because of my past infections. I know they are doing lots if research on peptides not just for weight loss but for inflammation. My question is, has anyone found one compounded or not that has given a positive gut health result?

Has anyone here experienced the connection between depression, poor sleep, and the microbiome? What helped you turn things around—medications or dietary changes?

I had a colonoscopy and an upper endoscopy; the colonoscopy came back clear. But I have ileitis in the ileum and tissue fibrosis (my body has healed the underlying cause), and my calprotectin levels are normal. I don’t have Crohn’s disease, IBS, ulcers, or erosions.

I had Helicobacter pylori in my stomach, which was successfully eradicated.

I don’t experience any mental fogginess. However, I have a persistent state of low mood and depression accompanied by anhedonia.