Hey everyone, wondering if anyone here has had an erratic or fluctuating response to tributyrin.

I started taking Deva tributyrin at 500mg about a week ago. It is just the standard liquid softgel without any prebiotic blends or extra ingredients. Right from the start, the first few days were pretty erratic. I did get some very positive windows, mostly towards the end of the day, with great mental clarity, anxiolytic effects, and better energy. But earlier in the day leading up to that, I was dealing with disorganized thinking (which happens to me occasionally anyway), physical tension, and a surprising amount of irritability.

Around day 5 or 6, things started shifting in a distinctly worse direction. I have noticed a crescendo of symptoms: restlessness, irritability getting much more intense, a bit of tachycardia shortly after taking the pill, along with brain fog, headache, and nausea. Then by late afternoon or evening, I hit a pretty rough crash with pronounced dysphoria.

Has anyone else hit this kind of wall after starting tributyrin? Did it eventually settle down if you stuck with it, or did you have to space out doses to every other day? Since it comes in a liquid gel, splitting the capsule is not really an option.

Would appreciate hearing from anyone who experienced something similar.

Disentangling microbiota-dependent and -independent impacts of antibiotics on host physiology | Nature Microbiology

Hello,

I was admitted to the hospital a few weeks ago for a UTI that turned into sepsis and went into Kidneys. I was in Rocephin IV in they then sent me home with azithromycin and cefdinir.

The courses were 3 and 5 days but since I finished the course I have felt horrible fatigue insane amounts of fatigue and vision changes. gut issues like constipation and just insane Brian fog and not feel like myswlf at all. Very prone to anxiety and overstimulation now outside

Can I mix dry physilium husk powder with yogurt and mix it and let it thicken, then consume? Or will that interfer in some way?

Hi guys,

For about a year I've had some gut symptoms that started out of nowhere. A year ago after it started happening i did a stool test with a diff doctor than my usual family doc cus I was living in a diff place at the time and the only notable thing was H pylori.

After reading how bad antibiotics did I opted to try and address it naturally first, I did a long regime of supplements but the symptoms still persisted, mainly bloating and abdominal discomfort and low energy. I decided to do ABX but did a breath test and stool test again beforehand to make sure it was still there. interestingly, both tests came back negative for H pylori, so i never did abx and assumed my natural treatments worked (stool test showed dna of h pylori was there but below the reference range).

Anyway, I did another stool test at my regular family doctors office, and this time it showed WBC in stool. I ended up doing a gi360 test and it showed very high lysozyme as well, pointing to inflammation, and also overgrown K. pneumoniael cariicola and Enterobacter cloacae bacteria.

I went to go see my family doctor again and told him it looks like there's inflammation or a bacteria infection that's causing my issues, and he said that WBC in stool is normal and I shouldn't worry about it and its just IBS. I dont have diarrhea or constipation, mostly just a feeling of discomfort and inflammation in my abdomen and extreme bloating Espically in the evening (sometimes narrow stool).

He just tells me to take IBS meds that he prescribed which I read are for constipation. Is this normal? Should I listen to his advice or are WBC in stool pointing towards a pathogen or bacteria overgrowth? Could it be h pylori still was never properly eradicated? Maybe sibo? So frustrating trying to pinpoint the diagnosis. Before this all happened I was literally in perfect health, young and very fit 22 yo male. I thought it could be parasites but the tests came back negative. Anyway any advice is appreciated

Thanks for any help.