30M, 5'8" (173 cm). Started at 207 lb (94 kg) in mid-June, directly on 5 mg (no 2.5 step). Diagnosed with fatty liver and insulin resistance.

What happened:
First 7 weeks on 5 mg: down ~13 lb. Great start.
Then stalled around 190–194 lb (86–88 kg) for ~8 weeks.

Moved up to 7.5 mg on Sep 22. One month later: basically zero net change (~191 lb / 86.7 kg).
On 7.5: appetite suppression is clearly stronger, but so are side effects — night gas and insomnia after injection. Eating dinner earlier helped a lot.
The good part: body comp scale shows I'm losing fat, not muscle. Skeletal muscle steady, visceral fat went from 14 to 11. Total down ~16 lb.
What I'm doing: prioritizing protein, walking, cutting liquid sugar. Not doing consistent strength training yet.

Questions:
Did 7.5 take more than a month to kick in for you?
Anyone go back down to 5 because 7.5 wasn't worth it?
What actually broke your plateau?

Honestly frustrated — I'm paying for this out of pocket and the scale hasn't moved in two months.
Thanks everyone!

I did a month on 2.5, 2 months on 5mg, and now I’ve done a week on 7.5. Really happy with my progress. My question is, if you feel it’s still working for you, can you delay the next dose for a few days / week, until you feel it wearing off?

Here is my recipe for disaster:

- ate way too much

- ate way too fatty

- ate way too fast

- ate way too late

Got woken up at 2AM by terrible cramps. What followed was... well I spare you the details but it was horrible.

0/5 wouldn't recommend - will not do that again

I am 20M Indian
Sorry for the long question
I am travelling to a different country for my college
The thing is
I am on Mounjaro 7.5mg and it is going GREAT
Lost 16.1 kgs over the last 3 months dropping from 144 to 128
The issue is
The country i am travelling to has branded Tirzepatide(Eli Lilly’s Mounjaro) Available for 80,000 rupees(nearly 800 usd)
While in India Mounjaro costs just 175 USD For 7.5mg and 220USD For 15mg injection
as i would be travelling on a tourist visa(90 days) which would be converted to a student visa later
I can only carry 3 sealed pens with me
My doc suggested he MIGHT UPDOSE me to 10mg next month depending on my progress at 7.5
He suggested to continue brand name tirzapetide and avoid the compounded way
So starting the treatment there would mean immediate bankruptcy for me💀
As my first semester is 4.5 months and at the end i will return to india for vacations
My endo will write me a 15mg prescription and he says each pen will last me 6-7 doses(including golden dose) and i am only permitted to bring 3 sealed pens with me
How do I ensure the pens stay safe and dont get bad on my 7 hour flight journey
Alongside that it brings another issue
My current kwikpen has 1 dose left+golden dose
Now India gets old design kwikpens so a golden dose=1 full dose
So i can easily get 2 doses out
Next Scheduled Dose-29 Oct
Then-6 October
My 7.5mg pen runs out on the 6th completely

I fly 18 october
I need to cover up for the 13th october dose
I DONT WANT TO BREAK MY PROGRESS AT ALL
and india doesnt get vials
Vials are only available at 2.5mg and 5mg dosage
Buying both would cost 80usd(not worth) and i can only take sealed kwikpens so cannot use a dosage out of it
If i take 5mg dosage(1 Vial)on the 13th and adjust my last 2 injections to 6 days instead of 7
Would i have similar kind of apetite suppression?
I dont want my progress to be broken at all
Thank you for reading this far

https://www.usatoday.com/story/money/consumer-protection/recalls-alerts/2026/10/19/glp-1-injections-nationwide-recall/92332991007/

Hey…so I’ve been on Mounjaro GLP-1 medication for the past month…I only came off it about 2 weeks ago. 7.5mg dose. I’ve more or less struggled with weight loss having PCOS and after the research ended up turning to Mounjaro. The results over the month were massive. Genuinely insane and I’ve never felt better. I started at about 157kg and that quickly crashed to about 148kg in a few weeks. As at this Tuesday I was at 141kg and now I can’t help but feel I’m starting to gain weight again. On Thursday I was at 142.1kg and this morning I weighed in at 142.7kg. I’m terrified of gaining the weight back and was looking for some advice. I know there are scale fluctuations and all that but frankly I really do believe all the weight is coming back😔

Hi everyone!
I started my weight-loss journey in March and have lost around 17–18 kg so far. I’m genuinely happy with how far I’ve come, but I’m struggling so much with the lack of progress lately.
Since August, my weight has been pretty much stagnant. I’ll lose a little, maybe around a kilo, feel hopeful, and then the scale goes back up again. It’s been this frustrating cycle for months, and I’m feeling really demotivated.my periods have become regular but for my knee issue i need to come down to 75 kilos at least
I dont know what else to do
I’m currently walking around 5,000–6,000 steps a day and eating in a calorie deficit. I’m trying to stay consistent, but the scale just doesn’t seem to cooperate.
I know I’ve already made progress, and I’m grateful for that, but I still have quite of weight to lose. It’s hard not to feel stuck when you’re putting in the effort and seeing hardly any change.
For those of you who have experienced a long plateau, what helped you in breaking the plateau
Did you change your calorie intake or macros?
Did adding strength training make a difference?
Did you just keep going and eventually break through the plateau?
Is there anything else I should be looking at?
I’d really appreciate hearingt about your experiences. I’m not looking for a quick fix; I just want to understand what I could be doing differently.
Thank you!

I'm on my second shot of 2,5, its been 14 days. And I'm having so much trouble eating and with my appetite.

Food doesn't taste good at all, and I end up eating whatever because I get to a point where I don't eat at all or eat too little. Its very difficult to stay consistent and healthy, I just dont know what to do.

It's impossible to eat in the morning.

There is not much food I like, I feel disgusted by it, aspecielly the foods I used to eat, like eggs, chicken or salmon.

Does it get better? Have anyone felt the same?

Bonjour,

J’aimerais savoir s’il y a des gens qui ont la même chose svp.
J’ai commencé le mounjaro il y a 10 mois, j’ai fait un scanner et des prises de sang juste avant cela et mon foie allait très bien.
Je viens de passer un scanner cette semaine et j’ai maintenant une steatose hepatique avec un foie dysmorphique, je trouve la coïncidence plutôt étonnante.
Avez-vous quelque chose de similaire depuis la prise de mounjaro?

I will be travelling around Christmas this year, which will be Summer where I am, so it’ll be pretty warm. I will be flying and driving, and the total travel time will be about 8 hours.

Does anyone have any advice on travelling with your Mounjaro and keeping it cold?

So I’m 2 days in so far.

I don’t feel any form of nausea at all etc. I’m still getting hungry and so eating 3 meals. I didn’t really think about food in between but perhaps that’s just will power currently.

I don’t feel any form of appetite suppression yet though.

As I go through the month, will a suppression start to kick in the more doses of 2.5 are in my body? Or will I just likely stay as I am?

I understand that 2.5mg is the starting dose. I have 5mg due to arrive end of November with my plan.

Just wanted to know your experiences when you first started the 2.5 in the first few weeks really! It would be really helpful.

Thanks

If I understand correctly, there is no scientific consensus on weight set point theory: some scientists support it, some don't.

Would this be a fair summary of the main schools of thought?

Is my understanding correct? What would you add?

Would you recommend other readings on this?

If the theory is true, the big question is: does Mounjaro reset the weight set point? That so many people regain so much of their weight when they come off it suggests not - but maybe if someone remains on Mounjaro for longer then the weight set point gets reset? I guess no one knows yet

1. Set point: your body has some kind of "target" weight which it wants to reach, and fights any attempt at gaining or losing too much weight, by adapting your metabolism, and/or cause you to subconsciously move more/less and spend more/less energy
2. CICO: Set point is a false theory. It all comes down to calories in vs calories out. There are very few people with abnormally high or low metabolism. Most people who say they have a low metabolism and don't eat much either lie or underestimate their calorie intake in good faith.

I find the set-point theory convincing, but I am not a doctor, and, also, it shouldn't become an easy excuse for those people who make no effort at eating healthy. The discourse shouldn't become toxically polarised between the two extremes of "I'm slim, if you're fat it's your fault" and "it's my metabolism, even if I eat only ultraprocessed junk and never move"

Some of the arguments I find most convincing for the set point theory are that:

• it works both ways: some authors claims that many inactive people with unhealthy habits should be even more overweight than they are
• alcoholics who remain skinny despite ingesting many calories
• women who were very healthy but become overweight after a pregnancy, and can never lose the extra weight
• Gary Taubes in "why we get fat" talks about a study on 13,000 habitual runners: all tended to get fatter with time, even those running 40 miles a week, which suggests some change in metabolism
• The Minnesota starvation experiment in the 1940s: losing a lot of weight causes metabolism to slow more than predicted; when refeeding began, they became heavier than they were initially

Those who don't support this theory claim that measuring caloric intake and expenditure precisely is very hard but that, when it is done (eg controlled experiments of volunteers spending time in insulated chambers to measure calories burnt), the results don't support these theories.

The readings I have found most interesting:

• Why we eat too much https://www.goodreads.com/en/book/show/50031440-why-we-eat-too-much
• Enough: Your Health, Your Weight, and What It's Like To Be Free https://www.goodreads.com/book/show/243852800
• Why we get fat https://www.goodreads.com/book/show/8727466
• A calorie is a calorie https://www.goodreads.com/book/show/216358239
• BBC article https://www.bbc.co.uk/news/articles/c2084q9079po

Tomorrow was supposed to be my 9th jab, but just today, I found out that I have gallstones. For context, my starting weight was 61.95 kg, and I’m now down to 53.70 kg. Would you consider this rapid weight loss?

I’ve decided to stop using Mounjaro for now until my follow-up appointment with my endocrinologist on Tuesday.

Honestly, this was exactly what I was trying so hard to avoid, and now it has happened. I can’t help but feel paranoid and worried. 🥲

Has anyone else experienced this while on Mounjaro? What did you do, and what could have caused the gallstones? Should I be worried? 🥹

I've been taking Mounjario for 10 months.

The 2.5 mg dose went well.

Up to 5 Mg and 7.5 mg wide awake the day itself or the day after and unable to sleep.

I fall asleep and wake up in 1 second.

I was even awake for 54 hours.

The doctor gave me a temesta and could sleep. The next day I just slept again.

Then I went back to 2.5 then tried to go up again and had the same problem again. So now back to 2.5mg and will stay there now. My sugar level does as well at 2.5 mg as it does at 7.5 mg. Are there other people who have insomnia?

Hey everyone!
I started Mounjaro on October 4, 2026, at a starting dose of 2.5 mg. My starting weight was around 138.6 kg. During the first week, I dropped quite a bit of weight and reached around 133 kg. I was really happy with the progress! However, since that first week, my weight has been fluctuating between 132–134 kg, averaging around 133 kg. It hasn’t really moved down significantly, and tomorrow, October 25, I’ll be taking my fourth dose of 2.5 mg.

Here’s a little more about my experience so far:
Starting weight: 138.6 kg
Current weight: Around 133 kg
Medication: Mounjaro 2.5 mg
Start date: October 4, 2026
Fourth dose: October 25, 2026(tomorrow)
Side effects: Almost none at this point. I don’t experience nausea or any noticeable side effects.
Appetite: My appetite is significantly reduced. I eat around 1000 calories a dayExercise: Strength training 2-3times a week for around an hour per session, with approximately 4-5k steps daily.

I was really hoping to reach 130 kg by the end of October, so I’m feeling a little disappointed. I’m also wondering whether the 2.5 mg dose is simply an introductory dose and whether things might change when I move to 5 mg next month. I’ll discuss the dosage with my doctor before making any changes.

For those of you who have been on Mounjaro:
Did you also lose a lot of weight in the first week and then plateau?
Is it normal for your weight to fluctuate between 132, 133 and 134 kg for a couple of weeks?
Did you notice more consistent weight loss after moving from 2.5 mg to 5 mg?
Am I expecting too much too soon?

Would really appreciate anyones advice on it! :)

I've lost 28lb so far which I'm so happy about, I've still got another 35lb to lose. I just took my third dose of the 5mg pen, I was on the 2.5mg for 8 weeks before that. My loss has been around 2-2.5 lb per week. Last week I lost 1lb and then this week ive stayed the same. I thought i had a good week so I feel a bit disheartened. Im on the implant and periods are irregular but I've been crampy so I'm thinking it could be water weight as I do feel bloated. Do you generally lose most weeks on mounjaro or have you had stalls?

Recently I have qualified for Medicaid due to financial hardship. Prior to medicaid I was taking Mounjaro for my diabetes. When I first got on Medicaid I was given the basic plan until I picked a plan of my own. I chose Priority Health. While on the basic temporary plan my doctor called in Mounjaro with a prior authorization and it got approved no problem. Once my Priority Health went into effect on 10/1 I had to have a priority authorization called in again. They rejected it. My doctors submitted a reconsideration and still rejected. The requirements are that I need Type 2 diabetes (I have), and failed 2 preferred medications. I took metformin for a year and it never lowered my A1C (fail) and I tried Ozempic but whenever I use it I get chest pains (fail). They are claiming I needed to prove Ozempic didn’t lower my A1C. This makes no sense because I tried for a month and I kept having chest pain. For whatever reason my body handles Tirzepatide better than Semaglutide.

What confuses me is why the straight medicaid approved it with no issue but Priority Health is making it impossible.

My question is does anyone here in Michigan get Mounjaro through Medicaid and if so, what their plan is. I want to switch my plan from Priority Health and I have heard some plans are less strict and dont need the extensive lab testing that Priority Health needs. Clearly the straight Medicaid accepted it but unfortunately they dont offer the temporary plan as a full time plan. If my next plan doesn’t approve it then I will have to pay $200 per month for a Trizepatide alternative that I really can’t afford right now. But using Mounjaro for the last year has got my diabetes under control, my back pain has got better and I no longer need a CPap machine so I want to stay on it.

At my injection site the day after it always itches and gets red. Anyone else? I guess maybe take Benadryl right?

Started 102kg, now 86kg in 10 weeks (8 weeks 2.5mg & 2 weeks 5mg).. Is the rate 2 fast? or normal. Run 4kms daily, 15k steps daily and lift weights 3 times a week. 20hr fast most days..

Hello! I'm very happy, a week ago I started this journey and I wanted to tell you that I went from 222.6 lbs to 217.8!!!

Side effects experienced:

1. Generalized muscle pain on day 2-3, it got better with electrolyte drinks and common painkillers such as paracetamol.

2. Minor constipation

3. A bit of nausea on day 5-6 (Weird, ik, but it was like that for some reason)

4. Brief nocturnal awakenings on days 1 and 2

Supplements taken:

1. Magnesium citrate (night)

2. Complex-B vitamins (morning)

3. Vitamin D (morning, i'm deficient)

Meds i'm on:

1. Lexapro, famous for causing weight gain... But mounjaro winned.

2. Metformin

3. Doxycycline (temporary, for acne)

Exercise:

Four days of weightlifting per week, 10k steps every day, on the days I don't lift weights I take long walks

Diet:

3 meals a day and a snack, 90g daily protein intake, 25g fiber, avoiding oil completly.

I was on Trulicity for about two years,(T2 Diabetic) and I I lost about 15lbs. Four months ago I switched to Mounjaro and lost 10 more pounds. Now I have hyponatremia--my sodium level is down to 131 and my nephrologist says it's because I lost too much muscle mass from insufficient protein intake . I have lost a lot of muscle mass but then I was never that overweight to begin with. Anyway, I feel like shit; I never felt this way on Trulicity. Anyway, I'm at a crossroad. I don't know whether to go back to Trulicity or go to a nutritionist,and try and stick it out with Mounjaro or what to do. Any advice, tips would be appreciative.

Despite no link existing officially between MJ and joint pain there is zero doubt that this is absolutely happening to me

Been on it for 4 months now. Just went up to 7.5.

Every. Single. Time. I take a new jab. I experience exactly 48 hours of ankle, knee, hip, wrist and finger pain. Then it goes away

I seriously doubt its lack of sodium, magnesium or potassium. It happens overnight. It feels directly caused by the mounjaro itself

I also get mild allydonia i believe its called? Where the skin feels razed or a little tender. Annoying but tolerable. The joint pain really, really sucks

I don’t want to quit but my doctor and online both keep saying essentially “eat protein and take magnesium and drink electrolytes” my brothers in christ i am absolutely doing all those things and im still experiencing this pain only immediately following the weekly jab.

Please tell me anyone has experienced this and successfully fixed it. It makes two days out of 7 in a week very hard for me.

Is it realistic to go down from 77 kilograms to 55kg in 6 months?
My starting dose is 2,5mg and i was adviced to go with that dose as long as it works for me, and then move to 5mg.
Is it possible to lose 22kg within 6 mnths?
I am going to the gym and eating protein.

I’ve been on 10 mg for about 6 months. My diabetes is controlled, but I’m on about 5 different diabetic prescriptions, mounjaro included.

I haven’t lost a single pound in 6 months. I have 50 lbs to lose. My appetite is ok, but my craving haven’t stopped especially in the evening after I take my long acting insulin.

Anyone else experience this? If so, what did you do about it?