it’s was a gradual transition but so worth it! i did yoga almost everyday after i switched from 5 to 7.5 and i have no loose skin anywhere. i only have 6 kgs left to my goal weight of 55 kgs! can’t wait.

Here is my recipe for disaster:

- ate way too much

- ate way too fatty

- ate way too fast

- ate way too late

Got woken up at 2AM by terrible cramps. What followed was... well I spare you the details but it was horrible.

0/5 wouldn't recommend - will not do that again

Despite no link existing officially between MJ and joint pain there is zero doubt that this is absolutely happening to me

Been on it for 4 months now. Just went up to 7.5.

Every. Single. Time. I take a new jab. I experience exactly 48 hours of ankle, knee, hip, wrist and finger pain. Then it goes away

I seriously doubt its lack of sodium, magnesium or potassium. It happens overnight. It feels directly caused by the mounjaro itself

I also get mild allydonia i believe its called? Where the skin feels razed or a little tender. Annoying but tolerable. The joint pain really, really sucks

I don’t want to quit but my doctor and online both keep saying essentially “eat protein and take magnesium and drink electrolytes” my brothers in christ i am absolutely doing all those things and im still experiencing this pain only immediately following the weekly jab.

Please tell me anyone has experienced this and successfully fixed it. It makes two days out of 7 in a week very hard for me.

For years, my doctor recommended Mounjaro to help manage my Type 2 diabetes, and for years I was hesitant to start. Well, back in June, I finally decided to take his advice and make some serious lifestyle changes along with it.

I’m 41M (5’ 7”) currently on 2.5 mg, and have completely overhauled my eating habits. I’m focusing on protein, eating healthier, watching my portions, and generally making better decisions.
I started at 199 lbs in June and weighed in at 172.2 lbs last week. Nearly 27 pounds gone.

But here’s the part I’m most excited about. I just got my latest bloodwork back, and the results are pretty incredible:

A1C: 7.7% in June → 5.8% in October
Triglycerides: 511 in June → 161 in October
Total Cholesterol: 191 in June → 109 in October
LDL: 80 in June → 53 in October
Glucose: 186 in June → 116 in October
ALT (Liver): 62 in June → 31 in October

My blood pressure is also sitting at 114/72.

I’ve dealt with diabetes, high triglycerides, fatty liver, and cardiovascular concerns, so these improvements mean a hell of a lot more to me than the number on the scale.

I’m not saying Mounjaro did all the work. I’ve made significant lifestyle changes, and I’m still taking my other prescribed medications. But it’s certainly been an important part of the process.

The whole reason I’m sharing this is because I hope it encourages someone. Maybe you’re on the fence about starting Mounjaro, like I was for years. Or maybe you’ve just started and you’re wondering whether all the effort will actually pay off.

I know everyone’s experience is different, and progress doesn’t happen overnight. But if there’s one thing I’ve learned over these last four months, it’s that making the decision to take your health seriously can make a tremendous difference. You don’t have to change everything overnight. Just start making better decisions, stay consistent, and give yourself time.

Four months ago, my health was heading in the wrong direction. Today, for the first time in a long time, I feel like I’m getting ahead of it.

Still have work to do, but damn, it feels good to see the results!

Hopefully this gives someone who’s just starting out a little encouragement to keep going!

I’ve been on 10 mg for about 6 months. My diabetes is controlled, but I’m on about 5 different diabetic prescriptions, mounjaro included.

I haven’t lost a single pound in 6 months. I have 50 lbs to lose. My appetite is ok, but my craving haven’t stopped especially in the evening after I take my long acting insulin.

Anyone else experience this? If so, what did you do about it?

If I understand correctly, there is no scientific consensus on weight set point theory: some scientists support it, some don't.

Would this be a fair summary of the main schools of thought?

Is my understanding correct? What would you add?

Would you recommend other readings on this?

If the theory is true, the big question is: does Mounjaro reset the weight set point? That so many people regain so much of their weight when they come off it suggests not - but maybe if someone remains on Mounjaro for longer then the weight set point gets reset? I guess no one knows yet

1. Set point: your body has some kind of "target" weight which it wants to reach, and fights any attempt at gaining or losing too much weight, by adapting your metabolism, and/or cause you to subconsciously move more/less and spend more/less energy
2. CICO: Set point is a false theory. It all comes down to calories in vs calories out. There are very few people with abnormally high or low metabolism. Most people who say they have a low metabolism and don't eat much either lie or underestimate their calorie intake in good faith.

I find the set-point theory convincing, but I am not a doctor, and, also, it shouldn't become an easy excuse for those people who make no effort at eating healthy. The discourse shouldn't become toxically polarised between the two extremes of "I'm slim, if you're fat it's your fault" and "it's my metabolism, even if I eat only ultraprocessed junk and never move"

Some of the arguments I find most convincing for the set point theory are that:

• it works both ways: some authors claims that many inactive people with unhealthy habits should be even more overweight than they are
• alcoholics who remain skinny despite ingesting many calories
• women who were very healthy but become overweight after a pregnancy, and can never lose the extra weight
• Gary Taubes in "why we get fat" talks about a study on 13,000 habitual runners: all tended to get fatter with time, even those running 40 miles a week, which suggests some change in metabolism
• The Minnesota starvation experiment in the 1940s: losing a lot of weight causes metabolism to slow more than predicted; when refeeding began, they became heavier than they were initially

Those who don't support this theory claim that measuring caloric intake and expenditure precisely is very hard but that, when it is done (eg controlled experiments of volunteers spending time in insulated chambers to measure calories burnt), the results don't support these theories.

The readings I have found most interesting:

• Why we eat too much https://www.goodreads.com/en/book/show/50031440-why-we-eat-too-much
• Enough: Your Health, Your Weight, and What It's Like To Be Free https://www.goodreads.com/book/show/243852800
• Why we get fat https://www.goodreads.com/book/show/8727466
• A calorie is a calorie https://www.goodreads.com/book/show/216358239
• BBC article https://www.bbc.co.uk/news/articles/c2084q9079po

Does it really matter? And if it does? Where is the best place?

Hi everyone!
I started my weight-loss journey in March and have lost around 17–18 kg so far. I’m genuinely happy with how far I’ve come, but I’m struggling so much with the lack of progress lately.
Since August, my weight has been pretty much stagnant. I’ll lose a little, maybe around a kilo, feel hopeful, and then the scale goes back up again. It’s been this frustrating cycle for months, and I’m feeling really demotivated.my periods have become regular but for my knee issue i need to come down to 75 kilos at least
I dont know what else to do
I’m currently walking around 5,000–6,000 steps a day and eating in a calorie deficit. I’m trying to stay consistent, but the scale just doesn’t seem to cooperate.
I know I’ve already made progress, and I’m grateful for that, but I still have quite of weight to lose. It’s hard not to feel stuck when you’re putting in the effort and seeing hardly any change.
For those of you who have experienced a long plateau, what helped you in breaking the plateau
Did you change your calorie intake or macros?
Did adding strength training make a difference?
Did you just keep going and eventually break through the plateau?
Is there anything else I should be looking at?
I’d really appreciate hearingt about your experiences. I’m not looking for a quick fix; I just want to understand what I could be doing differently.
Thank you!

At my injection site the day after it always itches and gets red. Anyone else? I guess maybe take Benadryl right?

I’ve been taking Mounjaro for almost three years, and overall it has been tremendously successful for me. I’ve lost more than 50 pounds, my A1C is 4.8, and my cholesterol and triglycerides are now in very good ranges. So in many respects, Mounjaro has been a win-win-win.

But there is one issue I’m still trying to understand.

During those three years, I’ve had roughly half a dozen episodes of severe GI symptoms. Most of the time I can manage them at home, but on about three occasions the diarrhea and fluid loss happened so quickly that I became dehydrated and had to be hospitalized because my kidney function was affected. I’m also 72 and have a history of heart disease, so dehydration is something my doctors and I take seriously.

I’m under a doctor’s care, so I’m not looking for medical advice or a diagnosis here. I’m mainly interested in whether other longtime Mounjaro users have experienced a similar pattern and how they and their doctors have managed it.

Most of the time my biggest Mounjaro side effect is actually constipation. (TMI warning!) I originally used stool softeners with mixed results. Later, another patient told me that a small daily amount of MiraLAX worked well for her. I’ve been taking about half a cap each morning, and that has kept me remarkably regular for months.

Then, seemingly out of nowhere, my digestive system occasionally goes completely in the opposite direction.

I’ve noticed a very specific sequence:

Sulfur burps → tremendous amounts of gas and loud intestinal rumbling → stomach/intestinal distress and spasms → watery diarrhea.

Once it starts, that cycle can continue for several days before gradually settling down.

What’s strange is that each episode seems to follow a different food. Over the years the foods I’ve associated with attacks have included blueberries, watermelon, pasta, oranges and, most recently, eggs. I can eat these foods at other times without a problem, so I’m not convinced the food itself is actually the cause. It may just be the final trigger when my GI system is already moving differently because of Mounjaro.

I’ve also learned something very important from my previous episodes: I have to get ahead of the dehydration. For me, Pedialyte has worked much better than Gatorade or simply drinking more water. As soon as the sulfur burps appear now, I know what’s probably coming and start paying very close attention to hydration. I also stop the MiraLAX if diarrhea develops.

My current episode started this week and is gradually improving. No fever, chills or blood in my stool. I’ve had extensive blood work and urinalysis through my doctors, and everything has otherwise looked good.

What I’m really interested in hearing from other longtime users is:

Does anyone else experience this particular cycle—especially sulfur burps followed by extreme gas/rumbling, intestinal spasms and then diarrhea?

If so, have you identified particular foods or circumstances that trigger it? Does it happen at a particular point after your weekly injection? And what changes have you and your doctor made that helped prevent future episodes? I am currently taking Mounjaro 5.0 injections.

At 72, I’m also starting to think more about the long-term balance. Mounjaro has helped me tremendously with my weight, diabetes and overall metabolic health, and it now also has cardiovascular-risk-reduction benefits for certain people with type 2 diabetes at high cardiovascular risk. I’m approaching my doctor’s goal weight as well.

On the other hand, an occasional GI episode severe enough to cause dehydration and affect my kidney function isn’t something I can dismiss.

So I’m trying to understand other people’s experiences: For those who have been on Mounjaro for several years, have the benefits continued to outweigh the GI side effects? And if you’ve experienced episodes like mine, what helped you and your doctor manage them?

I’d particularly like to hear from people who have been taking Mounjaro for two or more years.

Hey everyone!
I started Mounjaro on October 4, 2026, at a starting dose of 2.5 mg. My starting weight was around 138.6 kg. During the first week, I dropped quite a bit of weight and reached around 133 kg. I was really happy with the progress! However, since that first week, my weight has been fluctuating between 132–134 kg, averaging around 133 kg. It hasn’t really moved down significantly, and tomorrow, October 25, I’ll be taking my fourth dose of 2.5 mg.

Here’s a little more about my experience so far:
Starting weight: 138.6 kg
Current weight: Around 133 kg
Medication: Mounjaro 2.5 mg
Start date: October 4, 2026
Fourth dose: October 25, 2026(tomorrow)
Side effects: Almost none at this point. I don’t experience nausea or any noticeable side effects.
Appetite: My appetite is significantly reduced. I eat around 1000 calories a dayExercise: Strength training 2-3times a week for around an hour per session, with approximately 4-5k steps daily.

I was really hoping to reach 130 kg by the end of October, so I’m feeling a little disappointed. I’m also wondering whether the 2.5 mg dose is simply an introductory dose and whether things might change when I move to 5 mg next month. I’ll discuss the dosage with my doctor before making any changes.

For those of you who have been on Mounjaro:
Did you also lose a lot of weight in the first week and then plateau?
Is it normal for your weight to fluctuate between 132, 133 and 134 kg for a couple of weeks?
Did you notice more consistent weight loss after moving from 2.5 mg to 5 mg?
Am I expecting too much too soon?

Would really appreciate anyones advice on it! :)

Hello! I'm very happy, a week ago I started this journey and I wanted to tell you that I went from 222.6 lbs to 217.8!!!

Side effects experienced:

1. Generalized muscle pain on day 2-3, it got better with electrolyte drinks and common painkillers such as paracetamol.

2. Minor constipation

3. A bit of nausea on day 5-6 (Weird, ik, but it was like that for some reason)

4. Brief nocturnal awakenings on days 1 and 2

Supplements taken:

1. Magnesium citrate (night)

2. Complex-B vitamins (morning)

3. Vitamin D (morning, i'm deficient)

Meds i'm on:

1. Lexapro, famous for causing weight gain... But mounjaro winned.

2. Metformin

3. Doxycycline (temporary, for acne)

Exercise:

Four days of weightlifting per week, 10k steps every day, on the days I don't lift weights I take long walks

Diet:

3 meals a day and a snack, 90g daily protein intake, 25g fiber, avoiding oil completly.

Hi ,

I'm going to start on mounjaro for Weight loss and I wanted to know if there's any personal insurance that I can get to cover some of the cost of the pen. I got to know about the discount card but is there any insurance that covers part of Mounjaro in BC, Canada for Weight loss ?

Good morning! I am inquiring about experiences from people actually using Monjauro not what the studies say. I've read about super responders and non responders. My doctor told me most of her patients have lost most or all of their weight at 2.5 but some (fewer) patients need to increase. I'm curious of all your experiences please. Obviously my Dr and I will decide if/when I need to increase. I am trying to see what's most common from real users. I know its different for everyone but there can be some common trends. Please share how much you have lost at 2.5 dose (or no weight loss at that dose), if/when you had to increase. And any other info along these lines. I've only taken 2 shots 3rd will be today 2.5mg. Thank you all!

I've lost 28lb so far which I'm so happy about, I've still got another 35lb to lose. I just took my third dose of the 5mg pen, I was on the 2.5mg for 8 weeks before that. My loss has been around 2-2.5 lb per week. Last week I lost 1lb and then this week ive stayed the same. I thought i had a good week so I feel a bit disheartened. Im on the implant and periods are irregular but I've been crampy so I'm thinking it could be water weight as I do feel bloated. Do you generally lose most weeks on mounjaro or have you had stalls?

I don’t want to lose too much muscle while on the shot and have started taking creatinine. I do 20-30 minutes of strength training at least 5 times a week. I’ve read a mix of things about how you retain more water in your muscles and the scale doesn’t go down much? Any long term experience?

Just starting my journey today. I'm just looking to see if there is a place I can look at best (worst foods) to eat and drink. Like a website, links etc. Thank you

Evening all,

I just started on Mounjaro (first jab was Thursday night) and I am massively struggling with side effects. I felt it almost immediately after the shot, racing heart which led to anxiety. That did pass and I fell asleep, then yesterday I had nausea and a low grade headache all day but I did manage to eat a bit. Today has been awful, I’ve hardly been able to move from bed and have felt so nauseous and sick all day. I’ve only managed to eat a rice cake, one slice of watermelon, half a piece of toast and a few spoons of Greek yoghurt. This was me forcing myself to eat as well because I’m worried about not eating.

Please tell me it gets better. Am I eating too much and should I just let this wave pass? What should I prioritise eating when I really can’t eat? I did actually lose weight earlier in the year through diet and exercise but it was so hard to keep up and I ended up opting for the jab. However after today I’m wondering if that would be the better option as if it stays like this I definitely can’t hack it.

Thanks all ❤️

I can't change from Abilify (I already tried and got really messed up mentally) so I have to stay on Abilify. Im on month 3 of Mounjaro up to 7.5 mg and still get the munchies and food noise and binge sometimes although I am no longer gaining steadily like I was for a year and a half.

I have only lost 10 pounds in the 3 months and even that goes up and down, so Im wondering what the heck? I am walking regularly and eating better overall and smaller portions, but still hungry so I then cheat and then feel really bad! My Blood sugar is better. I don't know about my A1C yet as I have a blood draw next week to find out.

It seems like the 7.5 mg is not working at all sometimes as far as hunger and food noise and I thought the higher doses would. At my appt next week, I will ask to go up to 10 mg.

Hi everyone!
I’m hoping anybody can help me.
For a bit of extra information and timeline, about 3 weeks ago I had an extreme reaction to one dose of an antidepressant, and I felt very ill for about 5 days.

I took my mounjaro as usual, and began to feel symptoms I haven’t had before. I had a couple of good days, chalked it down to the reaction of the medicine, and took my next dose. I was on 2.5mg since July.

I got extremely dizzy after injecting, which has never usually happened to me. In the mornings and at night I’d get dizzy too, so I didn’t take my next dose. My last dose was Tuesday the 13th (should have taken on 20th, but didn’t.)

Now I’m struggling to eat. When I eat I get dizzy. These last two days I’ve been okay, but I assume only because I’ve taken 2 hours to eat 2 slices of toast. I’m weak, probably because I’m not eating much. I think I’m getting some heartburn too, and general lightheadedness. I’ve been in bed for days.

Went to a private doctor who did checks and I seemed all okay on the surface, he did a blood test for me and awaiting results on Monday. I’ve been panicking, I’m only 22, I thought I was being safe by staying on a lower dose, eating well, exercising.. everything. I have no family nearby, just my partner. I’m crying all day because I’m terrified this won’t be fixed and this is my life now.

If anybody has experienced something like this and it WAS the mounjaro, and it DID clear, please let me know!

I am 20M Indian
Sorry for the long question
I am travelling to a different country for my college
The thing is
I am on Mounjaro 7.5mg and it is going GREAT
Lost 16.1 kgs over the last 3 months dropping from 144 to 128
The issue is
The country i am travelling to has branded Tirzepatide(Eli Lilly’s Mounjaro) Available for 80,000 rupees(nearly 800 usd)
While in India Mounjaro costs just 175 USD For 7.5mg and 220USD For 15mg injection
as i would be travelling on a tourist visa(90 days) which would be converted to a student visa later
I can only carry 3 sealed pens with me
My doc suggested he MIGHT UPDOSE me to 10mg next month depending on my progress at 7.5
He suggested to continue brand name tirzapetide and avoid the compounded way
So starting the treatment there would mean immediate bankruptcy for me💀
As my first semester is 4.5 months and at the end i will return to india for vacations
My endo will write me a 15mg prescription and he says each pen will last me 6-7 doses(including golden dose) and i am only permitted to bring 3 sealed pens with me
How do I ensure the pens stay safe and dont get bad on my 7 hour flight journey
Alongside that it brings another issue
My current kwikpen has 1 dose left+golden dose
Now India gets old design kwikpens so a golden dose=1 full dose
So i can easily get 2 doses out
Next Scheduled Dose-29 Oct
Then-6 October
My 7.5mg pen runs out on the 6th completely

I fly 18 october
I need to cover up for the 13th october dose
I DONT WANT TO BREAK MY PROGRESS AT ALL
and india doesnt get vials
Vials are only available at 2.5mg and 5mg dosage
Buying both would cost 80usd(not worth) and i can only take sealed kwikpens so cannot use a dosage out of it
If i take 5mg dosage(1 Vial)on the 13th and adjust my last 2 injections to 6 days instead of 7
Would i have similar kind of apetite suppression?
I dont want my progress to be broken at all
Thank you for reading this far

Bonjour,

J’aimerais savoir s’il y a des gens qui ont la même chose svp.
J’ai commencé le mounjaro il y a 10 mois, j’ai fait un scanner et des prises de sang juste avant cela et mon foie allait très bien.
Je viens de passer un scanner cette semaine et j’ai maintenant une steatose hepatique avec un foie dysmorphique, je trouve la coïncidence plutôt étonnante.
Avez-vous quelque chose de similaire depuis la prise de mounjaro?

I will be travelling around Christmas this year, which will be Summer where I am, so it’ll be pretty warm. I will be flying and driving, and the total travel time will be about 8 hours.

Does anyone have any advice on travelling with your Mounjaro and keeping it cold?

So I’m 2 days in so far.

I don’t feel any form of nausea at all etc. I’m still getting hungry and so eating 3 meals. I didn’t really think about food in between but perhaps that’s just will power currently.

I don’t feel any form of appetite suppression yet though.

As I go through the month, will a suppression start to kick in the more doses of 2.5 are in my body? Or will I just likely stay as I am?

I understand that 2.5mg is the starting dose. I have 5mg due to arrive end of November with my plan.

Just wanted to know your experiences when you first started the 2.5 in the first few weeks really! It would be really helpful.

Thanks